Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy

Desiree De Simoni; Gerda Ricken; Michael Winklehner; Inga Koneczny; Michael Karenfort; Ulf Hustedt; Ulrich Seidel; Omar Abdel-Mannan; Pinki Munot; Simon Rinaldi; Claudia Steen; Michael Freilinger; Markus Breu; Rainer Seidl; Markus Reindl; Julia Wanschitz; Cinta Lleixà; Günther Bernert; Klaus-Peter Wandinger; Ralf Junker; Luis Querol; Frank Leypoldt; Kevin Rostásy; Romana Höftberger

doi:10.1212/NXI.0000000000000763

Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy

Desiree De Simoni, Gerda Ricken, Michael Winklehner, Inga Koneczny, Michael Karenfort, Ulf Hustedt, Ulrich Seidel, Omar Abdel-Mannan, Pinki Munot, Simon Rinaldi, Claudia Steen, Michael Freilinger, Markus Breu, Rainer Seidl, Markus Reindl, Julia Wanschitz, Cinta Lleixà, Günther Bernert, Klaus-Peter Wandinger, Ralf JunkerLuis Querol, Frank Leypoldt, Kevin Rostásy, Romana Höftberger

Division of Neurology (University Hospital St. Pölten)

Research output: Journal article (peer-reviewed) › Journal article

22 Citations (Scopus)

Abstract

Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).1.

Original language	English
Article number	e763
Journal	Neurology: Neuroimmunology and NeuroInflammation
Volume	7
Issue number	4
DOIs	https://doi.org/10.1212/NXI.0000000000000763
Publication status	Published - 01 Jul 2020

Keywords

Adolescent
Autoantibodies
Cell Adhesion Molecules, Neuronal/immunology
Child
Child, Preschool
Female
Guillain-Barre Syndrome/immunology
Humans
Infant
Male
Nerve Growth Factors/immunology
Nodal Protein/immunology
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology
Retrospective Studies

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10.1212/NXI.0000000000000763

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De Simoni, D., Ricken, G., Winklehner, M., Koneczny, I., Karenfort, M., Hustedt, U., Seidel, U., Abdel-Mannan, O., Munot, P., Rinaldi, S., Steen, C., Freilinger, M., Breu, M., Seidl, R., Reindl, M., Wanschitz, J., Lleixà, C., Bernert, G., Wandinger, K.-P., ... Höftberger, R. (2020). Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy. Neurology: Neuroimmunology and NeuroInflammation, 7(4), Article e763. https://doi.org/10.1212/NXI.0000000000000763

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title = "Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy",

abstract = "Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barr{\'e} syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).1.",

keywords = "Adolescent, Autoantibodies, Cell Adhesion Molecules, Neuronal/immunology, Child, Child, Preschool, Female, Guillain-Barre Syndrome/immunology, Humans, Infant, Male, Nerve Growth Factors/immunology, Nodal Protein/immunology, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology, Retrospective Studies",

author = "\{De Simoni\}, Desiree and Gerda Ricken and Michael Winklehner and Inga Koneczny and Michael Karenfort and Ulf Hustedt and Ulrich Seidel and Omar Abdel-Mannan and Pinki Munot and Simon Rinaldi and Claudia Steen and Michael Freilinger and Markus Breu and Rainer Seidl and Markus Reindl and Julia Wanschitz and Cinta Lleix{\`a} and G{\"u}nther Bernert and Klaus-Peter Wandinger and Ralf Junker and Luis Querol and Frank Leypoldt and Kevin Rost{\'a}sy and Romana H{\"o}ftberger",

note = "Publisher Copyright: {\textcopyright} American Academy of Neurology.",

year = "2020",

month = jul,

day = "1",

doi = "10.1212/NXI.0000000000000763",

language = "English",

volume = "7",

journal = "Neurology: Neuroimmunology and NeuroInflammation",

issn = "2332-7812",

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De Simoni, D, Ricken, G, Winklehner, M, Koneczny, I, Karenfort, M, Hustedt, U, Seidel, U, Abdel-Mannan, O, Munot, P, Rinaldi, S, Steen, C, Freilinger, M, Breu, M, Seidl, R, Reindl, M, Wanschitz, J, Lleixà, C, Bernert, G, Wandinger, K-P, Junker, R, Querol, L, Leypoldt, F, Rostásy, K & Höftberger, R 2020, 'Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy', Neurology: Neuroimmunology and NeuroInflammation, vol. 7, no. 4, e763. https://doi.org/10.1212/NXI.0000000000000763

TY - JOUR

T1 - Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy

AU - De Simoni, Desiree

AU - Ricken, Gerda

AU - Winklehner, Michael

AU - Koneczny, Inga

AU - Karenfort, Michael

AU - Hustedt, Ulf

AU - Seidel, Ulrich

AU - Abdel-Mannan, Omar

AU - Munot, Pinki

AU - Rinaldi, Simon

AU - Steen, Claudia

AU - Freilinger, Michael

AU - Breu, Markus

AU - Seidl, Rainer

AU - Reindl, Markus

AU - Wanschitz, Julia

AU - Lleixà, Cinta

AU - Bernert, Günther

AU - Wandinger, Klaus-Peter

AU - Junker, Ralf

AU - Querol, Luis

AU - Leypoldt, Frank

AU - Rostásy, Kevin

AU - Höftberger, Romana

N1 - Publisher Copyright: © American Academy of Neurology.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).1.

AB - Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).1.

KW - Adolescent

KW - Autoantibodies

KW - Cell Adhesion Molecules, Neuronal/immunology

KW - Child

KW - Child, Preschool

KW - Female

KW - Guillain-Barre Syndrome/immunology

KW - Humans

KW - Infant

KW - Male

KW - Nerve Growth Factors/immunology

KW - Nodal Protein/immunology

KW - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology

KW - Retrospective Studies

UR - https://www.scopus.com/pages/publications/85085908924

U2 - 10.1212/NXI.0000000000000763

DO - 10.1212/NXI.0000000000000763

M3 - Journal article

C2 - 32487720

SN - 2332-7812

VL - 7

JO - Neurology: Neuroimmunology and NeuroInflammation

JF - Neurology: Neuroimmunology and NeuroInflammation

IS - 4

M1 - e763

ER -

Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy

Abstract

Keywords

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