An update on recent developments and highlights in food allergy

Arielle Locke, Lisa Hung, Julia E M Upton, Liam O'Mahony, Jennifer Hoang, Thomas Eiwegger

Research output: Journal article (peer-reviewed)Review article

3 Citations (Scopus)

Abstract

While both the incidence and general awareness of food allergies is increasing, the variety and clinical availability of therapeutics remain limited. Therefore, investigations into the potential factors contributing to the development of food allergy and the mechanisms of natural tolerance or induced desensitization are required. In addition, a detailed understanding of the pathophysiology of food allergies is needed to generate compelling, enduring, and safe treatment options. New findings regarding the contribution of barrier function, the effect of emollient interventions, mechanisms of allergen recognition, and the contributions of specific immune cell subsets through rodent models and human clinical studies provide novel insights. With the first approved treatment for peanut allergy, the clinical management of food allergy is evolving towards less intensive, alternative approaches involving fixed doses, lower maintenance dose targets, co-administration of biologicals, adjuvants, and tolerance-inducing formulations. The ultimate goal is to improve immunotherapy and develop precision-based medicine via risk phenotyping allowing optimal treatment for each food-allergic patient.

Original languageEnglish
Pages (from-to)2344-2360
Number of pages17
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume78
Issue number9
Early online date23 Apr 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • barrier function
  • food allergy
  • immune response
  • immunotherapy
  • mouse models

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'An update on recent developments and highlights in food allergy'. Together they form a unique fingerprint.

Cite this