An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients

Florian Scheichel, Daniel Pinggera, Branko Popadic, Camillo Sherif, Franz Marhold, Christian Franz Freyschlag

Research output: Journal article (peer-reviewed)Review article

9 Citations (Scopus)


Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients.

Original languageEnglish
Article number884724
Pages (from-to)884724
JournalFrontiers in Oncology
Publication statusPublished - 20 Apr 2022


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