Age Related Osteoporosis: Targeting Cellular Senescence

Ursula Föger-Samwald, Katharina Kerschan-Schindl, Maria Butylina, Peter Pietschmann

Research output: Journal article (peer-reviewed)Review article

Abstract

Age-related chronic diseases are an enormous burden to modern societies worldwide. Among these, osteoporosis, a condition that predisposes individuals to an increased risk of fractures, substantially contributes to increased mortality and health-care costs in elderly. It is now well accepted that advanced chronical age is one of the main risk factors for chronical diseases. Hence, targeting fundamental aging mechanisms such as senescence has become a promising option in the treatment of these diseases. Moreover, for osteoporosis, the main pathophysiological concepts arise from menopause causing estrogen deficiency, and from aging. Here, we focus on recent advances in the understanding of senescence-related mechanisms contributing to age-related bone loss. Furthermore, treatment options for senile osteoporosis targeting senescent cells are reviewed.

Original languageEnglish
Article number2701
JournalInternational Journal of Molecular Sciences
Volume23
Issue number5
DOIs
Publication statusPublished - 1 Mar 2022

Keywords

  • Aged
  • Aging/physiology
  • Cellular Senescence/physiology
  • Chronic Disease
  • Female
  • Humans
  • Osteoporosis/therapy

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