Abstract
OBJECTIVE: To investigate fetal/neonatal and obstetric events in pregnancies with both maternal and fetal heart disease.
STUDY DESIGN: From the CARPREG database, singleton pregnancies (>24 weeks) in patients with structural heart disease that underwent fetal/neonatal echocardiograms were selected and separated in two groups: maternal heart disease only (M-HD) and maternal and fetal heart disease (MF-HD). Differences in adverse fetal/neonatal (death, preterm birth, and small for gestational age) and obstetric (preeclampsia/eclampsia) outcomes between groups were analyzed.
RESULTS: From 1011 pregnancies, 93 had MF-HD. Fetal/neonatal events (38.7% vs 25.3%, p = 0.006) and spontaneous preterm birth (10.8% vs 4.9%, p = 0.021) were more frequent in MF-HD compared to M-HD, with no difference in obstetric events. MF-HD remained as a significant predictor of fetal/neonatal events after adjustment (OR:1.883; 95% CI:1.182-3.000; p = 0.008).
CONCLUSIONS: Pregnancies with MF-HD are at risk of adverse fetal/neonatal events and spontaneous preterm birth. Larger studies are needed to determine their association with preeclampsia.
| Original language | English |
|---|---|
| Pages (from-to) | 1424-1431 |
| Number of pages | 8 |
| Journal | Journal of Perinatology |
| Volume | 44 |
| Issue number | 10 |
| Early online date | 23 Jul 2024 |
| DOIs | |
| Publication status | Published - Oct 2024 |
Keywords
- Pre-Eclampsia/epidemiology
- Echocardiography
- Humans
- Pregnancy Complications, Cardiovascular/epidemiology
- Logistic Models
- Gestational Age
- Pregnancy
- Ultrasonography, Prenatal
- Heart Diseases
- Premature Birth/epidemiology
- Female
- Adult
- Infant, Small for Gestational Age
- Retrospective Studies
- Infant, Newborn
- Pregnancy Outcome
- Fetal Diseases/epidemiology