Adipose derived stem cells to target osteoarthritis: Basic science and clinical applications

Markus Neubauer, Theodor Seist, Dietmar Dammerer, Stefan Nehrer*

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Review article


Osteoarthritis (OA) is a common and debilitating disease. It is accompanied by pain and a progressive loss of mobility. Mesenchymal stem cells (MSCs) were shown to be a potential treatment option for OA. Their mode of action is subject of current research. MSCs’ paracrine factors – such as growth factors and exosomes – play a key role in altering the diseased joint homeostasis in a beneficial way. A traditional MSC source tissue was bone marrow aspirate. Recently, adipose tissue has become an alternative MSC source due to a variety of advantages such as a lower harvest morbidity and the abundance of the tissue. MSCs derived from the infra-patellar fat pad were shown to possess superior conditions compared to other adipose sources. Blood product supplementation was shown to further enhance MSCs viability. We conducted a mini-review about adipose-derived MSCs in OA treatment with regards to basic science, status of translation and current clinical applications. Promising data – both from clinical trials as well as from basic research – support beneficial effects of adipose derived MSCs in OA. However, at the moment general recommendations cannot be given due to a lack of high-quality clinical data warranting further research in the field.

Translated title of the contributionStammzellen aus Fettgewebe gegen Osteoarthritis: Basis-Wissenschaft und klinische Anwendungen
Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalSports Orthopaedics and Traumatology
Issue number2
Publication statusPublished - Jun 2023


  • Adipose-derived mesenchymal stem cell
  • Infra patellar fat pad
  • Knee arthroscopy
  • Osteoarthritis

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine


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