ABCD3-I score and the risk of early or 3-month stroke recurrence in tissue- and time-based definitions of TIA and minor stroke

Austrian Stroke Unit Collaborators, Alexander Tinchon

Research output: Journal article (peer-reviewed)Journal article

19 Citations (Scopus)


Changing definition of TIA from time to a tissue basis questions the validity of the well-established ABCD3-I risk score for recurrent ischemic cerebrovascular events. We analyzed patients with ischemic stroke with mild neurological symptoms arriving < 24 h after symptom onset in a phase where it is unclear, if the event turns out to be a TIA or minor stroke, in the prospective multi-center Austrian Stroke Unit Registry. Patients were retrospectively categorized according to a time-based (symptom duration below/above 24 h) and tissue-based (without/with corresponding brain lesion on CT or MRI) definition of TIA or minor stroke. Outcome parameters were early stroke during stroke unit stay and 3-month ischemic stroke. Of the 5237 TIA and minor stroke patients with prospectively documented ABCD3-I score, 2755 (52.6%) had a TIA by the time-based and 2183 (41.7%) by the tissue-based definition. Of the 2457 (46.9%) patients with complete 3-month followup, corresponding numbers were 1195 (48.3%) for the time- and 971 (39.5%) for the tissue-based definition of TIA. Early and 3-month ischemic stroke occurred in 1.1 and 2.5% of time-based TIA, 3.8 and 5.9% of time-based minor stroke, 1.2 and 2.3% of tissue-based TIA as well as in 3.1 and 5.5% of tissue-based minor stroke patients. Irrespective of the definition of TIA and minor stroke, the risk of early and 3-month ischemic stroke steadily increased with increasing ABCD3-I score points. The ABCD3-I score performs equally in TIA patients in tissue- as well as time-based definition and the same is true for minor stroke patients.

Original languageEnglish
Pages (from-to)530-534
Number of pages5
JournalJournal of Neurology
Issue number3
Publication statusPublished - 01 Mar 2018


  • Aged
  • Aged, 80 and over
  • Brain/diagnostic imaging
  • Female
  • Follow-Up Studies
  • Humans
  • Ischemic Attack, Transient/diagnosis
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prospective Studies
  • Recurrence
  • Registries
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Stroke/diagnosis
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Transient ischemic attack
  • Tissue-based
  • ABCD3-I
  • Risk prediction
  • Time-based
  • Minor stroke

ASJC Scopus subject areas

  • Neurology (clinical)
  • Neurology


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