A Review on Recent Advances in the Constitutive Modeling of Bone Tissue

Research output: Journal article (peer-reviewed)Review article

21 Citations (Scopus)


PURPOSE OF REVIEW: Image-based finite element analysis (FEA) to predict and understand the biomechanical response has become an essential methodology in musculoskeletal research. An important part of such simulation models is the constitutive material model of which recent advances are summarized in this review.

RECENT FINDINGS: The review shows that existing models from other fields were introduced, such as cohesion zone (cortical bone) or phase-field models (trabecular bone). Some progress has been made in describing cortical bone involving physical mechanisms such as microcracks. Problems with validations at different length scales remain a problem. The improvement of recent constitutive models is partially obscured by uncertainties that affect overall predictions, such as image quality and calibration or boundary conditions. Nevertheless, in vivo CT-based FEA simulations based on a sophisticated constitutive behavior are a very valuable tool for clinical-related osteoporosis research.

Original languageEnglish
Pages (from-to)696-704
Number of pages9
JournalCurrent Osteoporosis Reports
Issue number6
Publication statusPublished - Dec 2020


  • Animals
  • Biomechanical Phenomena
  • Bone Remodeling/physiology
  • Finite Element Analysis
  • Humans
  • Osteoporosis/physiopathology
  • Bone tissue
  • Constitutive model
  • Material law
  • Trabecular bone
  • Review article
  • Cortical bone
  • Finite element

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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