A review of the sequelae of post Covid-19 with neurological implications (post-viral syndrome)

Walter Struhal*, Doaa Almamoori

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

1 Citation (Scopus)

Abstract

Post Covid-19 conditions represent a medical challenge; a unified definition is not achieved after 5 years of the Pandemic. The incidence of Post Covid-19 conditions varies, nevertheless the neurological complications represent an important aspect in the spectrums of fields involved. The current perception is that varied manifestations and long-term complications of COVID-19 reflect underlying pathophysiological processes, including inflammatory, immune-mediated, and vascular mechanisms. These mechanisms underscore the complexity of COVID-19's impact including the nervous system and its potential for lasting effects. A number of symptoms are extremely severe and may also need neurologic attention including fatigue, cognitive disturbances, autonomic symptoms, headache, and sleep disorders. Post Covid-19 conditions are often of chronic nature. Management as in other chronic conditions should rely on the conventional diagnostic measures and management of symptoms irrespective of the temporal relation to the viral infection. To date Post Covid-19 conditions is only accepted as an additional or explanatory diagnosis.

Original languageEnglish
Article number123532
Pages (from-to)123532
JournalJournal of the Neurological Sciences
Volume474
Early online date12 May 2025
DOIs
Publication statusPublished - 15 Jul 2025

Keywords

  • Humans
  • COVID-19/complications
  • Nervous System Diseases/etiology
  • Post-Acute COVID-19 Syndrome
  • SARS-CoV-2
  • Long covid-19
  • Neurological sequelae of post Covid-19
  • Neurological complications of covid-19
  • Post Covid-19
  • Post viral
  • Review of post Covid-19

ASJC Scopus subject areas

  • Neurology
  • Neurology (clinical)

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