A review of particle therapy for skull base tumors: Modern considerations and future directions

Eugen B. Hug*, MacIej Pelak, Steven J. Frank, Piero Fossati

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

4 Citations (Scopus)

Abstract

Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.

Original languageEnglish
Pages (from-to)168-178
Number of pages11
JournalInternational Journal of Particle Therapy
Volume8
Issue number1
DOIs
Publication statusPublished - 01 Jun 2021
Externally publishedYes

Keywords

  • Carbon ion therapy
  • Chordoma
  • Particle therapy
  • Proton beam therapy
  • Skull base tumors

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Radiology, Nuclear Medicine and Imaging

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