A quantitative comparison of the performance of three deformable registration algorithms in radiotherapy

Daniella Fabri, Valentina Zambrano, Amon Bhatia, Hugo Furtado, Helmar Bergmann, Markus Stock, Christoph Bloch, Carola Lütgendorf-Caucig, Supriyanto Pawiro, Dietmar Georg, Wolfgang Birkfellner*, Michael Figl

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

21 Citations (Scopus)


We present an evaluation of various non-rigid registration algorithms for the purpose of compensating interfractional motion of the target volume and organs at risk areas when acquiring CBCT image data prior to irradiation. Three different deformable registration (DR) methods were used: the Demons algorithm implemented in the iPlan Software (BrainLAB AG, Feldkirchen, Germany) and two custom-developed piecewise methods using either a Normalized Correlation or a Mutual Information metric (featureletNC and featureletMI). These methods were tested on data acquired using a novel purpose-built phantom for deformable registration and clinical CT/CBCT data of prostate and lung cancer patients. The Dice similarity coefficient (DSC) between manually drawn contours and the contours generated by a derived deformation field of the structures in question was compared to the result obtained with rigid registration (RR). For the phantom, the piecewise methods were slightly superior, the featureletNC for the intramodality and the featureletMI for the intermodality registrations. For the prostate cases in less than 50% of the images studied the DSC was improved over RR. Deformable registration methods improved the outcome over a rigid registration for lung cases and in the phantom study, but not in a significant way for the prostate study. A significantly superior deformation method could not be identified.

Original languageEnglish
Pages (from-to)279-290
Number of pages12
JournalZeitschrift fur Medizinische Physik
Issue number4
Publication statusPublished - Dec 2013
Externally publishedYes


  • Deformable registration
  • Organ motion
  • Radiotherapy

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology, Nuclear Medicine and Imaging


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