@article{895349958f3f44cf8fb38d213e1aeadd,
title = "A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles",
abstract = "Background: Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy. Methods: Immunoglobulin E (IgE) sensitization profiles were determined in more than 2800 sera from children in nine population-based cohorts in different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB (the United Kingdom), GINIplus (Germany)], and south [INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)] using the MeDALL-allergen chip. Results: Sensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5-sensitization dominated in North and West/Central Europe. Conclusion: We show regional, exposome- and climate-dependent differences in molecular IgE-reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine-based approaches for treatment and prevention of allergy.",
keywords = "Europe, IgE reactivity, MeDALL chip, allergen molecules, exposome, sensitization profile",
author = "Kiewiet, {M B Gea} and Christian Lupinek and Susanne Vrtala and Sandra Wieser and Alexandra Baar and Renata Kiss and Inger Kull and Eric Mel{\'e}n and Magnus Wickman and Daniela Porta and Davide Gori and Ulrike Gehring and Rob Aalberse and Jordi Sunyer and Marie Standl and Joachim Heinrich and Dagmar Waiblinger and John Wright and Ant{\'o}, {Josep M} and Jean Bousquet and {van Hage}, Marianne and Rudolf Valenta",
note = "Funding Information: We thank Daniel Ebner, Thomas Schlederer, and Christian Harwanegg for excellent technical assistance regarding manufacturing of the customized allergen arrays which were made at Phadia Austria GmbH, Part of Thermo Fisher Scientific ImmunoDiagnostics, A-1220, Vienna, Austria. This paper is dedicated to Prof. Jean Bousquet for his amazing leadership in the MeDALL project. Funding Information: R.V. receives research grants from HVD Biotech, Vienna, Austria and Worg Pharmaceuticals, Hangzhou, China. He serves as consultant for Worg and Viravaxx AG, Vienna, Austria. MvH has received lecture fee from Thermo Fisher Scientific. GK has no conflict of interest to declare. CL and SW are currently employees of MacroArray Diagnostics GmbH, Vienna, Austria. JB reports personal fees from Cipla, Menarini, Mylan, Novartis, Purina, Sanofi‐Aventis, Teva, Uriach. He is shareholder of KYomed Innov and MASK‐air‐SAS. The rest of the authors report no conflict of interest. Funding Information: The study was supported by the European FP7‐program MeDALL, the Danube Allergy Research Cluster by the Country of Lower Austria, the Swedish Research Council, The Region Stockholm (ALF project), The Swedish Asthma and Allergy Association's Research Foundation, The Swedish Cancer and Allergy Foundation, The King Gustaf V 80th Birthday Foundation, The Swedish Heart‐Lung Foundation, The Hesselman Foundation, by the European Commission, by Mead Johnson, Evansville, Indiana, USA, by Nestle, Vevey, Vaud, Switzerland, by a Wellcome programme grant [WT223601/Z/21/Z: Age of Wonder, a UK Medical Research Council (MRC) and UK Economic and Social Science Research Council (ESRC) grant: MR/N02439/1 and by the special program (Programmi speciali‐Art. 12 bis, comma 6 D.lgs.229/99 Sanitaria e della Vigilanza sugli Enti)] funded by the Italian Ministry of Health. Publisher Copyright: {\textcopyright} 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.",
year = "2023",
month = jul,
doi = "10.1111/all.15689",
language = "English",
volume = "78",
pages = "2007--2018",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "7",
}