@article{973ba544743446b797ff5ec77f7c595f,
title = "A computational framework for canonical holistic morphometric analysis of trabecular bone",
abstract = "Bone is a remarkable, living tissue that functionally adapts to external loading. Therefore, bone shape and internal structure carry information relevant to many disciplines, including medicine, forensic science, and anthropology. However, morphometric comparisons of homologous regions across different individuals or groups are still challenging. In this study, two methods were combined to quantify such differences: (1) Holistic morphometric analysis (HMA) was used to quantify morphometric values in each bone, (2) which could then be mapped to a volumetric mesh of a canonical bone created by a statistical free-form deformation model (SDM). Required parameters for this canonical holistic morphometric analysis (cHMA) method were identified and the robustness of the method was evaluated. The robustness studies showed that the SDM converged after one to two iterations, had only a marginal bias towards the chosen starting image, and could handle large shape differences seen in bones of different species. Case studies were performed on metacarpal bones and proximal femora of different primate species to confirm prior study results. The differences between species could be visualised and statistically analysed in both case studies. cHMA provides a framework for performing quantitative comparisons of different morphometric quantities across individuals or groups. These comparisons facilitate investigation of the relationship between spatial morphometric variations and function or pathology, or both.",
keywords = "Animals, Bone and Bones, Cancellous Bone/diagnostic imaging, Femur, Primates",
author = "Sebastian Bachmann and Dunmore, {Christopher J} and Skinner, {Matthew M} and Pahr, {Dieter H} and Alexander Synek",
note = "Funding Information: This research has received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation program (Grant Agreement No. 819960). The authors are grateful to: Jean-Jacques Hublin (Coll{\`e}ge de France, Paris), Christophe Boesch and Uta Schwarz (MPI-EVA, Leipzig), Emmanuel Gilissen and Wim Welden (Royal Museum for Central Africa, Tervuren), Maria Teschler-Nicola and Ronald Muehl (Natural History Museum, Vienna), Jacopo Moggi-Cecchi and Silvia Bortoluzzi (University of Florence, Florence), and Birgit Gro{\ss}kopf (Johann-Friedrich-Blumenbach Institut f{\"u}r Zoologie und Anthropologie der Georg-August-Universit{\"a}t G{\"o}ttingen, G{\"o}ttingen), Inbal Livne (Powell-Cotton Museum, Birchington) and Nicole Edmison (Smithsonian Institution National Museum of Natural History NMNH, Washington D.C.), for access to specimens in their care. For technical assistance we would also like to thank Habiba Chirchir (Marshall University, Huntingdon), Patrick Schoenfeld and David Plotzki (MPI-EVA, Leipzig). Funding Information: This research has received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation program (Grant Agreement No. 819960). The authors are grateful to: Jean-Jacques Hublin (Coll{\`e}ge de France, Paris), Christophe Boesch and Uta Schwarz (MPI-EVA, Leipzig), Emmanuel Gilissen and Wim Welden (Royal Museum for Central Africa, Tervuren), Maria Teschler-Nicola and Ronald Muehl (Natural History Museum, Vienna), Jacopo Moggi-Cecchi and Silvia Bortoluzzi (University of Florence, Florence), and Birgit Gro{\ss}kopf (Johann-Friedrich-Blumenbach Institut f{\"u}r Zoologie und Anthropologie der Georg-August-Universit{\"a}t G{\"o}ttingen, G{\"o}ttingen), Inbal Livne (Powell-Cotton Museum, Birchington) and Nicole Edmison (Smithsonian Institution National Museum of Natural History NMNH, Washington D.C.), for access to specimens in their care. For technical assistance we would also like to thank Habiba Chirchir (Marshall University, Huntingdon), Patrick Schoenfeld and David Plotzki (MPI-EVA, Leipzig). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41598-022-09063-6",
language = "English",
volume = "12",
pages = "5187",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}