Unraveling the interactome of STAT3 isoforms in acute myeloid leukemia

This project aims to unravel the distinct and shared protein interaction networks of the STAT3α and STAT3β isoforms in acute myeloid leukemia (AML). By applying proximity-dependent biotin labeling (BioID) and mass spectrometry, the study will identify isoform-specific interactors and signaling partners both in vitro and in vivo. These findings are expected to reveal critical nodes within the JAK-STAT pathway that could serve as novel, more precise therapeutic targets. Ultimately, the project seeks to advance understanding of STAT3 signaling and contribute to the development of targeted, less toxic treatments for AML.