Tumor suppressors in acute myeloid leukemia

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Übersichtsartikel

6 Zitate (Scopus)

Abstract

Acute myeloid leukemia (AML) is a very heterogeneous type of blood cancer, which presents with a high rate of mortality especially in elderly patients. Better understanding of critical players, such as molecules with tumor suppressive properties, may help to fine-tune disease classification and thereby treatment modalities for this detrimental disease. Here, we summarize well-known and established tumor suppressors as well as emerging tumor suppressors, including transcription factors (TCFs) and other transcriptional regulators, such as epigenetic modulators. In addition, we look into the versatile field of miRNAs also interfering with tumorigenesis and progression, which offer new possibilities in AML diagnosis, prognosis, and therapy.

OriginalspracheEnglisch
Seiten (von - bis)2320-2330
Seitenumfang11
FachzeitschriftLeukemia and Lymphoma
Jahrgang62
Ausgabenummer10
DOIs
PublikationsstatusVeröffentlicht - Okt. 2021

ASJC Scopus Sachgebiete

  • Hämatologie
  • Onkologie
  • Krebsforschung

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