TY - JOUR
T1 - Thalidomide and lenalidomide
T2 - Mechanism-based potential drug combinations
AU - Vallet, Sonia
AU - Palumbo, Antonio
AU - Raje, Noopur
AU - Boccadoro, Mario
AU - Anderson, Kenneth C
PY - 2008/7
Y1 - 2008/7
N2 - Thalidomide and its analogue lenalidomide are potent anti-inflammatory, anti-angiogenic and immunomodulatory drugs, successfully used for the treatment of hematological cancers, in particular multiple myeloma (MM). Both drugs reveal a dual mechanism of action: they target tumour cells by direct cytotoxicity and, indirectly, by interfering with several components of the bone marrow microenvironment. Lenalidomide and thalidomide are versatile drugs with a broad range of activities that potentiate the anti-MM effects of conventional and novel agents. Here, we review the mechanism of action of these drugs, providing a rationale for combination studies in order to improve patient outcome and reduce side effects.
AB - Thalidomide and its analogue lenalidomide are potent anti-inflammatory, anti-angiogenic and immunomodulatory drugs, successfully used for the treatment of hematological cancers, in particular multiple myeloma (MM). Both drugs reveal a dual mechanism of action: they target tumour cells by direct cytotoxicity and, indirectly, by interfering with several components of the bone marrow microenvironment. Lenalidomide and thalidomide are versatile drugs with a broad range of activities that potentiate the anti-MM effects of conventional and novel agents. Here, we review the mechanism of action of these drugs, providing a rationale for combination studies in order to improve patient outcome and reduce side effects.
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Apoptosis/drug effects
KW - Bone Marrow/drug effects
KW - Humans
KW - Immune System/drug effects
KW - Lenalidomide
KW - Multiple Myeloma/drug therapy
KW - Thalidomide/analogs & derivatives
UR - http://www.scopus.com/inward/record.url?scp=47649085380&partnerID=8YFLogxK
U2 - 10.1080/10428190802005191
DO - 10.1080/10428190802005191
M3 - Review article
C2 - 18452080
SN - 1042-8194
VL - 49
SP - 1238
EP - 1245
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 7
ER -