TY - JOUR
T1 - Temporary Mechanical Circulatory Support and Shock Teams in High-Risk Cardiac Surgery
T2 - The Strategic Evolution of Protected Cardiac Surgery
AU - Salazar, Leonardo
AU - Nersesian, Gaik
AU - Meani, Paolo
AU - Bari, Gabor
AU - Mariani, Silvia
AU - Potapov, Evgenij
AU - Di Mauro, Michele
AU - Gelsomino, Sandro
AU - Milojevic, Milan
AU - Schmack, Bastian
AU - Stein, Louis
AU - Zimpfer, Daniel
AU - Wiedemann, Dominik
AU - Soltetz, Edward
AU - Bermudez, Christian
AU - Haft, Jonathan
AU - Moreno, Pedro
AU - Tonna, Joseph
AU - Takayama, Hiroo
AU - Lamarche, Yoan
AU - Rao, Vivek
AU - Faerber, Gloria
AU - Meyns, Bart
AU - Takeda, Koji
AU - Boeken, Udo
AU - MacLaren, Graeme
AU - Whitman, Glenn
AU - Patel, Bhavesh
AU - Silvestry, Scott
AU - Goldstein, Daniel J
AU - Arora, Rakesh C
AU - Engelman, Daniel T
AU - Lorusso, Roberto
N1 - Publisher Copyright:
Copyright © 2026. Published by Elsevier Inc.
PY - 2026/1/14
Y1 - 2026/1/14
N2 - Background Protected cardiac surgery is a proactive strategy that applies temporary mechanical circulatory support to prevent perioperative low cardiac output syndrome in high-risk cardiac surgery. Rather than escalating vasoactive agents after hemodynamic decline, the approach emphasizes early identification of physiologic vulnerability and timely initiation of support. Methods We conducted a structured literature review of peer-reviewed studies published from 2000 to 2024 on temporary mechanical circulatory support in adult cardiac surgery. There were 52 studies selected based on relevance to early or prophylactic support, timing of initiation, risk stratification, and systems of care. Clinical insights from multidisciplinary experts also informed the review framework. Results Inotropic escalation after hemodynamic deterioration is consistently associated with poor outcomes. High pharmacologic requirements and severe metabolic derangements predict very high mortality, whereas conventional risk scores often fail to identify vulnerable patients. In contrast, early initiation of mechanical support has been associated with lower in-hospital mortality, reduced dependence on vasoactive agents, and improved recovery. Physiologic markers, such as filling pressures and lactate levels, may provide earlier signals of circulatory decline. Effective implementation also requires institutional coordination, team-based planning, and regional referral systems. Conclusions Protected cardiac surgery reframes success in high-risk cardiac surgery by focusing on recovery rather than survival alone. It integrates physiology-guided support with structured planning and system-level readiness to improve outcomes in vulnerable surgical populations.
AB - Background Protected cardiac surgery is a proactive strategy that applies temporary mechanical circulatory support to prevent perioperative low cardiac output syndrome in high-risk cardiac surgery. Rather than escalating vasoactive agents after hemodynamic decline, the approach emphasizes early identification of physiologic vulnerability and timely initiation of support. Methods We conducted a structured literature review of peer-reviewed studies published from 2000 to 2024 on temporary mechanical circulatory support in adult cardiac surgery. There were 52 studies selected based on relevance to early or prophylactic support, timing of initiation, risk stratification, and systems of care. Clinical insights from multidisciplinary experts also informed the review framework. Results Inotropic escalation after hemodynamic deterioration is consistently associated with poor outcomes. High pharmacologic requirements and severe metabolic derangements predict very high mortality, whereas conventional risk scores often fail to identify vulnerable patients. In contrast, early initiation of mechanical support has been associated with lower in-hospital mortality, reduced dependence on vasoactive agents, and improved recovery. Physiologic markers, such as filling pressures and lactate levels, may provide earlier signals of circulatory decline. Effective implementation also requires institutional coordination, team-based planning, and regional referral systems. Conclusions Protected cardiac surgery reframes success in high-risk cardiac surgery by focusing on recovery rather than survival alone. It integrates physiology-guided support with structured planning and system-level readiness to improve outcomes in vulnerable surgical populations.
UR - https://www.scopus.com/pages/publications/105032283518
U2 - 10.1016/j.athoracsur.2025.12.032
DO - 10.1016/j.athoracsur.2025.12.032
M3 - Review article
C2 - 41544922
SN - 0003-4975
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
ER -