Targeting transcription factors in multiple myeloma: evolving therapeutic strategies

Shirong Li, Sonia Vallet, Antonio Sacco, Aldo Roccaro, Suzanne Lentzsch, Klaus Podar

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Übersichtsartikel

12 Zitate (Scopus)

Abstract

INTRODUCTION: Transcription factors (TFs) are convergence points of signaling cascades that coordinate cell differentiation, proliferation, survival, and migration; and are commonly deregulated in solid and hematologic malignancies, including multiple myeloma (MM). Several recent studies indicate that the inhibition of TFs may lead to selective tumor cell death with little or no consequences for normal cells due to redundancy in signaling pathways. Nuclear hormone receptor (NHR)- TFs belong to the most common therapies in oncology today. In contrast, non-NHR-TFs have been considered 'un- druggable' until most recently.

AREAS COVERED: This review article summarizes advances of our knowledge on the complex composition of non-NHR-TFs and their binding to cognate DNA sequences that are propelling the development of novel strategies in MM.

EXPERT OPINION: Protein-protein and protein-DNA- binding inhibitors, proteolysis- targeting chimeric molecules, and chromatin remodeling/epigenetic reader inhibitors are among the most promising novel compounds with a potentially high therapeutic index; they are likely to once more advance MM treatment strategies and improve patient outcome in the near future.

OriginalspracheEnglisch
Seiten (von - bis)445-462
Seitenumfang18
FachzeitschriftExpert Opinion on Investigational Drugs
Jahrgang28
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 04 Mai 2019

ASJC Scopus Sachgebiete

  • Pharmakologie (medizinische)
  • Pharmakologie

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