Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation

Moser Christian, Pohl Gudrun, Haslinger Isabella, Knapp Sylvia, Rowczenio Dorota, Russel Tonia, Lachmann Helen J., Lang Ursula, Kovarik Josef

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Artikel in Fachzeitschrift

109 Zitate (Scopus)


Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of fever and inflammation. The most severe complication of FMF is the development of AA amyloidosis, which can be life threatening. The only current effective treatment for FMF is colchicine. Regular prophylactic treatment with colchicine at a dose of 1–2 mg daily prevents or substantially reduces the clinical manifestations of FMF in at least 90% of cases. However, ∼10% of patients are reported to be resistant or non-responsive to colchicine and in these cases there is no consensus as to which second line agents should be used. We describe the first case, to our knowledge, of a patient with FMF and end-stage renal failure due to AA amyloidosis, successfully treated with IL-1 receptor blockade. Our data suggest that the IL-1 receptor antagonist Anakinra (Kineret®; r-metHuIL-1 ra) may represent a safe and effective therapy for the treatment of colchicine-resistant FMF, in patients r
Seiten (von - bis)676-678
FachzeitschriftNephrology Dialysis Transplantation
PublikationsstatusVeröffentlicht - Feb. 2009
Extern publiziertJa

ASJC Scopus Sachgebiete

  • Nephrologie
  • Transplantationsmedizin


Untersuchen Sie die Forschungsthemen von „Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren