@article{de48bf3bcce442aeab57935d9691aa28,
title = "Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL-8a mabtenance trial",
abstract = "No data are available regarding obesity and outcome in Chronic Lymphocytic Leukemia (CLL). We analyzed 263 patients from the AGMT CLL-8a Mabtenance trial for the impact of obesity. The trial included patients after rituximab-containing induction treatment in first or second line that had achieved at least a PR. A randomization to rituximab maintenance treatment (375 mg/m2 q3 months for 2 years) vs observation was performed. In this cohort 22% of the patients (58/263) were classified as obese. The baseline response to induction treatment was inferior in obese patients with a lower CR rate (43.1% vs 60.5% in obese vs non-obese, P = 0.018) and with a lower rate of patients achieving MRD negativity after chemoimmunotherapy induction treatment (19.6% vs 35.8%, P = 0.02). The PFS outcome of obese patients was significantly worse in the observation group of the trial (24 vs 39 months median PFS, P = 0.03). However, in the rituximab maintenance group the outcome for obese vs non-obese was not different (P = 0.4). In summary, obesity was overall associated with a worse outcome of chemoimmunotherapy induction. However, rituximab maintenance treatment seems to be able to overcome this negative effect.",
keywords = "Adult, Aged, Aged, 80 and over, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy, Maintenance Chemotherapy, Male, Middle Aged, Obesity/complications, Prognosis, Rituximab/administration & dosage, Survival Analysis, Treatment Outcome",
author = "Alexander Egle and Thomas Melchardt and Petra Obrtl{\'i}kov{\'a} and Luk{\'a}{\v s} Smolej and Tom{\'a}{\v s} Koz{\'a}k and Michael Steurer and Johannes Andel and Sonja Burgstaller and Eva Miku{\v s}kov{\'a} and Liana Gercheva and Thomas N{\"o}sslinger and Tom{\'a}{\v s} Papaj{\'i}k and Miriam Ladick{\'a} and Michael Girschikofsky and Mikul{\'a}{\v s} Hrubi{\v s}ko and Ulrich J{\"a}ger and Daniela Voskova and Martin Pecherstorfer and Eva Kr{\'a}likov{\'a} and Christina Burcoveanu and Emil Spasov and Andreas Petzer and Georgi Mihaylov and Julian Raynov and Horst Oexle and August Zabernigg and Em{\'i}lia Flochov{\'a} and Stanislav Pal{\'a}{\v s}thy and Olga Stehl{\'i}kov{\'a} and Michael Doubek and Petra Altenhofer and Lukas Weiss and Teresa Magnes and Lisa Pleyer and Anton Klingler and Ji{\v r}{\'i} Mayer and Richard Greil",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",
year = "2019",
month = apr,
doi = "10.1002/cam4.1980",
language = "English",
volume = "8",
pages = "1401--1405",
journal = "Cancer Medicine",
issn = "2045-7634",
publisher = "John Wiley and Sons Inc.",
number = "4",
}