TY - JOUR
T1 - Rheumatoid arthritis in remission
T2 - Decreased myostatin and increased serum levels of periostin
AU - Kerschan-Schindl, Katharina
AU - Ebenbichler, Gerold
AU - Föeger-Samwald, Ursula
AU - Leiss, Harald
AU - Gesslbauer, Christina
AU - Herceg, Malvina
AU - Stummvoll, Georg
AU - Marculescu, Rodrig
AU - Crevenna, Richard
AU - Pietschmann, Peter
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2019/1/1
Y1 - 2019/1/1
N2 - BACKGROUND: Chronic inflammation of rheumatoid arthritis (RA) is associated with disturbances in muscle and bone metabolism.AIM: The purpose of this study was to investigate whether endocrine regulators of myogenesis and bone metabolism in patients with rheumatoid arthritis (RA) in remission differed from unaffected healthy controls. An additional point was whether these were associated with patients' health-related functioning or particular bodily functions of the International Classification of Functioning, Disability and Health (ICF).METHODS: Bone turnover and the markers for muscle, i.e. myostatin (MSTN), follistatin (FSTN), growth differentiation factor (GDF-15) and for bone, i.e. sclerostin (SOST), dickkopf 1 (Dkk1), periostin (PSTN) metabolism were determined in 24 female RA patients and matched healthy controls. The chair rising test (CRT), timed up and go test (TUG), 6 min walking test, maximum hand grip and back extensor strength tests were used to assess patients' health-related functions. Additionally, bone mineral density of the lumbar spine and the hip region was measured.RESULTS: For the bone turnover markers no differences were observed between patients and controls. In contrast, the markers MSTN and Dkk1 were significantly lower and FSTN and PSTN significantly higher in patients than controls. Patients performed worse in the CRT and TUG. Some correlations reflected associations between these endocrine factors and physical function.CONCLUSION: Anti-inflammatory therapy may be responsible for the positive effect on endocrine factors influencing myogenesis. Elevation of PSTN probably reflects the increased risk of fragility fractures in RA patients.
AB - BACKGROUND: Chronic inflammation of rheumatoid arthritis (RA) is associated with disturbances in muscle and bone metabolism.AIM: The purpose of this study was to investigate whether endocrine regulators of myogenesis and bone metabolism in patients with rheumatoid arthritis (RA) in remission differed from unaffected healthy controls. An additional point was whether these were associated with patients' health-related functioning or particular bodily functions of the International Classification of Functioning, Disability and Health (ICF).METHODS: Bone turnover and the markers for muscle, i.e. myostatin (MSTN), follistatin (FSTN), growth differentiation factor (GDF-15) and for bone, i.e. sclerostin (SOST), dickkopf 1 (Dkk1), periostin (PSTN) metabolism were determined in 24 female RA patients and matched healthy controls. The chair rising test (CRT), timed up and go test (TUG), 6 min walking test, maximum hand grip and back extensor strength tests were used to assess patients' health-related functions. Additionally, bone mineral density of the lumbar spine and the hip region was measured.RESULTS: For the bone turnover markers no differences were observed between patients and controls. In contrast, the markers MSTN and Dkk1 were significantly lower and FSTN and PSTN significantly higher in patients than controls. Patients performed worse in the CRT and TUG. Some correlations reflected associations between these endocrine factors and physical function.CONCLUSION: Anti-inflammatory therapy may be responsible for the positive effect on endocrine factors influencing myogenesis. Elevation of PSTN probably reflects the increased risk of fragility fractures in RA patients.
KW - Adaptor Proteins, Signal Transducing
KW - Arthritis, Rheumatoid/blood
KW - Biomarkers/blood
KW - Bone Density
KW - Bone Morphogenetic Proteins
KW - Cell Adhesion Molecules/blood
KW - Cross-Sectional Studies
KW - Female
KW - Follistatin/blood
KW - Genetic Markers
KW - Hand Strength
KW - Humans
KW - Intercellular Signaling Peptides and Proteins/blood
KW - Myostatin/blood
KW - Postural Balance
KW - Remission, Spontaneous
KW - Time and Motion Studies
UR - http://www.scopus.com/inward/record.url?scp=85052962220&partnerID=8YFLogxK
U2 - 10.1007/s00508-018-1386-0
DO - 10.1007/s00508-018-1386-0
M3 - Journal article
C2 - 30171335
SN - 1613-7671
VL - 131
SP - 1
EP - 7
JO - Wiener Klinische Wochenschrift. The Central European Journal of Medicine
JF - Wiener Klinische Wochenschrift. The Central European Journal of Medicine
IS - 1-2
ER -