Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Mees Botman; Josje M A Huisman; Alexandra Drakaki; Sanne L Maas; Agnieszka Witalisz-Siepracka; Dagmar Stoiber; Emiel P C van der Vorst; Ricky Siebeler; Marten A Hoeksema

doi:10.1016/j.celrep.2026.116985

Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Mees Botman
, Josje M A Huisman
, Alexandra Drakaki
, Sanne L Maas
, Agnieszka Witalisz-Siepracka
, Dagmar Stoiber
, Emiel P C van der Vorst
, Ricky Siebeler
, Marten A Hoeksema

Fachbereich Pharmakologie

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

Abstract

Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.

Originalsprache	Englisch
Aufsatznummer	116985
Seiten (von - bis)	116985
Seitenumfang	1
Fachzeitschrift	Cell Reports
Jahrgang	45
Ausgabenummer	2
Frühes Online-Datum	10 Feb. 2026
DOIs	https://doi.org/10.1016/j.celrep.2026.116985
Publikationsstatus	Veröffentlicht - 24 Feb. 2026

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10.1016/j.celrep.2026.116985

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abstract = "Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.",

author = "Mees Botman and Huisman, \{Josje M A\} and Alexandra Drakaki and Maas, \{Sanne L\} and Agnieszka Witalisz-Siepracka and Dagmar Stoiber and \{van der Vorst\}, \{Emiel P C\} and Ricky Siebeler and Hoeksema, \{Marten A\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/",

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doi = "10.1016/j.celrep.2026.116985",

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AU - Botman, Mees

AU - Huisman, Josje M A

AU - Drakaki, Alexandra

AU - Maas, Sanne L

AU - Witalisz-Siepracka, Agnieszka

AU - Stoiber, Dagmar

AU - van der Vorst, Emiel P C

AU - Siebeler, Ricky

AU - Hoeksema, Marten A

PY - 2026/2/24

Y1 - 2026/2/24

N2 - Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.

AB - Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.

UR - https://www.scopus.com/pages/publications/105031635582

U2 - 10.1016/j.celrep.2026.116985

DO - 10.1016/j.celrep.2026.116985

M3 - Journal article

C2 - 41671082

SN - 2211-1247

VL - 45

SP - 116985

JO - Cell Reports

JF - Cell Reports

IS - 2

M1 - 116985

ER -

Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Abstract

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