Regional cerebral blood flow in patients suffering from post-traumatic stress disorder

S Mirzaei, P Knoll, A Keck, B Preitler, E Gutierrez, H Umek, H Köhn, M Pecherstorfer

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Artikel in Fachzeitschrift

30 Zitate (Scopus)

Abstract

OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.

METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.

RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.

CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.

OriginalspracheEnglisch
Seiten (von - bis)260-264
Seitenumfang5
FachzeitschriftNeuropsychobiology
Jahrgang43
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - 2001
Extern publiziertJa

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