TY - JOUR
T1 - Recent developments and highlights in mechanisms of allergic diseases
T2 - Microbiome
AU - Lunjani, Nonhlanhla
AU - Satitsuksanoa, Pattraporn
AU - Lukasik, Zuzanna
AU - Sokolowska, Milena
AU - Eiwegger, Thomas
AU - O'Mahony, Liam
N1 - Funding Information:
LOM is a consultant to Alimentary Health Ltd and has received research funding from GSK. NL, PS, ZL, MS and TE have no conflict of interest in relation to this work.
Publisher Copyright:
© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2018/12
Y1 - 2018/12
N2 - All body surfaces are exposed to a wide variety of microbes, which significantly influence immune reactivity within the host. This review provides an update on some of the critical novel findings that have been published on the influence of the microbiome on atopic dermatitis, food allergy and asthma. Microbial dysbiosis has consistently been observed in the skin, gut and lungs of patients with atopic dermatitis, food allergy and asthma, respectively, and the role of specific microbes in allergic disorders is being intensively investigated. However, many of these discoveries have yet to be translated into routine clinical practice.
AB - All body surfaces are exposed to a wide variety of microbes, which significantly influence immune reactivity within the host. This review provides an update on some of the critical novel findings that have been published on the influence of the microbiome on atopic dermatitis, food allergy and asthma. Microbial dysbiosis has consistently been observed in the skin, gut and lungs of patients with atopic dermatitis, food allergy and asthma, respectively, and the role of specific microbes in allergic disorders is being intensively investigated. However, many of these discoveries have yet to be translated into routine clinical practice.
KW - Asthma/microbiology
KW - Dermatitis, Atopic/microbiology
KW - Dysbiosis
KW - Food Hypersensitivity/microbiology
KW - Humans
KW - Hypersensitivity/microbiology
KW - Microbiota/immunology
UR - http://www.scopus.com/inward/record.url?scp=85056462716&partnerID=8YFLogxK
U2 - 10.1111/all.13634
DO - 10.1111/all.13634
M3 - Review article
C2 - 30325537
SN - 0105-4538
VL - 73
SP - 2314
EP - 2327
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 12
ER -