Real-time intensity based 2D/3D registration for tumor motion tracking during radiotherapy

Hugo Furtado, Christelle Gendrin, Christoph Bloch, Jakob Spoerk, Suprianto A. Pawiro, Christoph Weber, Michael Figl, Helmar Bergmann, Markus Stock, Dietmar Georg, Wolfgang Birkfellner

Publikation: Beitrag in Buch/Bericht/KonferenzbandBeitrag in Konferenzband

Abstract

Organ motion during radiotherapy is one of the causes of uncertainty in dose delivery creating the need to enlarge the planned target volume (PTV) to guarantee full tumor irradiation. In this work, we investigate the feasibility of using real-time 2D/3D registration for tumor motion tracking during radiotherapy based on purely intensity based image processing, thus avoiding markers or fiducials. X-rays are acquired during treatment at a rate of 5.4 Hz. We iteratively compare each x-ray with a set of digitally reconstructed radiographs (DRR) generated from the planning volume dataset, finding the optimal match between the xray and one of the DRRs. The DRRs are generated using a ray-casting algorithm, implemented using general purpose computation on graphics hardware (GPGPU) for best performance. Validation is conducted offline using a phantom and five clinical patient data sets. The phantom motion is measured with an RMS error of 2.1 mm and mean registration time is 220 ms. For the patient data sets, a sinusoidal movement that clearly correlates to the breathing cycle is seen. Mean registration time is always under 105 ms which is well suited for our purposes. These results demonstrate that real-time organ motion monitoring using image based markerless registration is feasible.

OriginalspracheEnglisch
TitelBildverarbeitung fur die Medizin 2012
UntertitelAlgorithmen - Systeme - Anwendungen, BVM 2012 - Proceedings des Workshops
Herausgeber (Verlag)Kluwer Academic Publishers
Seiten207-212
Seitenumfang6
ISBN (Print)9783642285011
DOIs
PublikationsstatusVeröffentlicht - 2012
Extern publiziertJa
VeranstaltungWorkshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2012 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2012 - Berlin, Deutschland
Dauer: 18 März 201220 März 2012

Publikationsreihe

NameInformatik aktuell
ISSN (Print)1431-472X

Konferenz

KonferenzWorkshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2012 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2012
Land/GebietDeutschland
OrtBerlin
Zeitraum18.03.1220.03.12

ASJC Scopus Sachgebiete

  • Modellierung und Simulation

Fingerprint

Untersuchen Sie die Forschungsthemen von „Real-time intensity based 2D/3D registration for tumor motion tracking during radiotherapy“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren