MM-associated anemia: more than "crowding out" HSPCs

Klaus Podar

doi:10.1182/blood-2012-05-425983

MM-associated anemia: more than "crowding out" HSPCs

Klaus Podar

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

1 Zitat (Scopus)

Abstract

In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.

Originalsprache	Englisch
Seiten (von - bis)	2539-2540
Seitenumfang	2
Fachzeitschrift	Blood
Jahrgang	120
Ausgabenummer	13
DOIs	https://doi.org/10.1182/blood-2012-05-425983
Publikationsstatus	Veröffentlicht - 27 Sept. 2012
Extern publiziert	Ja

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10.1182/blood-2012-05-425983

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title = "MM-associated anemia: more than {"}crowding out{"} HSPCs",

abstract = "In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.",

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author = "Klaus Podar",

year = "2012",

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day = "27",

doi = "10.1182/blood-2012-05-425983",

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T2 - more than "crowding out" HSPCs

AU - Podar, Klaus

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N2 - In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.

AB - In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.

KW - Animals

KW - Antigens, CD34/metabolism

KW - Biomarkers/metabolism

KW - Bone Marrow/pathology

KW - Female

KW - Hematopoietic Stem Cells/pathology

KW - Humans

KW - Male

KW - Megakaryocyte-Erythroid Progenitor Cells/pathology

KW - Multiple Myeloma/metabolism

UR - https://www.scopus.com/pages/publications/84866952765

U2 - 10.1182/blood-2012-05-425983

DO - 10.1182/blood-2012-05-425983

M3 - Journal article

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SN - 0006-4971

VL - 120

SP - 2539

EP - 2540

JO - Blood

JF - Blood

IS - 13

ER -

MM-associated anemia: more than "crowding out" HSPCs

Abstract

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