In-hospital outcomes and conditions in patients with acute coronary syndrome and coronary artery aneurysms who undergo percutaneous coronary intervention

Background: Coronary artery aneurysms (CAA) are uncommon, often incidental findings in patients with acute coronary syndrome (ACS) that represent a management challenge due to as there is a paucity of literature in this area. Methods: We analyzed the National Inpatient Sample database from 2016 to 2020 by including all patients with the admission diagnosis of the ACS who underwent percutaneous coronary intervention (PCI). We sought to evaluate the association of CAA with other relevant systemic conditions and determine the impact of CAA on in-hospital outcomes. Results: Among 1,733,655 hospital admission with ACS who underwent PCI, 2675 had CAA. There was a 2-fold increase in odds of CAA if the patient had coronary artery dissection (OR 2.05 95%CI 1.12–3.75, p = 0.020) or extracoronary aneurysm (OR 2.47 95%CI 1.46–4.16, p = 0.001) and a 3-fold increase in odds if they had a systematic inflammatory disorder (OR 3.24 95%CI 2.08–5.07, p < 0.001). CAA was not associated with increased odds of mortality (OR 1.22 95%CI 0.76–1.95, p = 0.42), bleeding (OR 1.29 95%CI 0.86–1.95, p = 0.22), acute stroke (OR 0.91 95%CI 0.40–2.07, p = 0.83), major adverse cardiac and cerebrovascular events (OR 1.08 95%CI 0.72–1.61, p = 0.71) or cardiac complications (OR 0.85 95%CI 0.49–1.47, p = 0.55). However, it was significantly associated with increased odds of vascular complications (OR 2.17 95%CI 1.47–3.19, p < 0.001). Conclusions: For patients with ACS who undergo PCI, the presence of CAA is associated with greater odds of vascular complications but after adjustments there was no difference in mortality or other complications. In this population, CAA is more prevalent in patients with coronary dissection, extracoronary aneurysms and systemic inflammatory disorders.