Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes

Pia Gattinger; Urska Bidovec-Stojkovic; Mihaela Zidarn; Peter Korosec; Rudolf Valenta; Irene Mittermann

doi:10.1016/j.jaci.2020.10.002

Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes

Pia Gattinger, Urska Bidovec-Stojkovic, Mihaela Zidarn, Peter Korosec, Rudolf Valenta, Irene Mittermann

Wissenschaftliche Arbeitsgruppe Allergologie und Immunologie

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

10 Zitate (Scopus)

Originalsprache	Englisch
Seiten (von - bis)	1502-1504.e5
Fachzeitschrift	Journal of Allergy and Clinical Immunology
Jahrgang	147
Ausgabenummer	4
DOIs	https://doi.org/10.1016/j.jaci.2020.10.002
Publikationsstatus	Veröffentlicht - Apr. 2021

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10.1016/j.jaci.2020.10.002

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title = "Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes",

keywords = "Allergens/chemistry, Animals, Basophils/immunology, Bee Venoms/immunology, Cell Line, Tumor, Epitopes/immunology, Glycosylation, Humans, Immunoglobulin E/immunology, Insect Proteins/chemistry, Phospholipases A/chemistry, Proteins/immunology, Rats, Recombinant Proteins/chemistry",

author = "Pia Gattinger and Urska Bidovec-Stojkovic and Mihaela Zidarn and Peter Korosec and Rudolf Valenta and Irene Mittermann",

note = "Funding Information: Disclosure of potential conflict of interest: R. Valenta has received research grants from HVD Life-Sciences, Vienna, Austria, and from Viravaxx, Vienna, Austria; in addition, he serves as consultant for Viravaxx. I. Mittermann has received a research grant from the Austrian Science Fund. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: This study was supported by grants from the Austrian Science Fund ( P26728 and F4605 ) and from HVD Biotech, Vienna, Austria and Viravaxx, Vienna, Austria. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. ",

year = "2021",

month = apr,

doi = "10.1016/j.jaci.2020.10.002",

language = "English",

volume = "147",

pages = "1502--1504.e5",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

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TY - JOUR

T1 - Glycosylation enhances allergenic activity of major bee venom allergen Api m 1 by adding IgE epitopes

AU - Gattinger, Pia

AU - Bidovec-Stojkovic, Urska

AU - Zidarn, Mihaela

AU - Korosec, Peter

AU - Valenta, Rudolf

AU - Mittermann, Irene

N1 - Funding Information: Disclosure of potential conflict of interest: R. Valenta has received research grants from HVD Life-Sciences, Vienna, Austria, and from Viravaxx, Vienna, Austria; in addition, he serves as consultant for Viravaxx. I. Mittermann has received a research grant from the Austrian Science Fund. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: This study was supported by grants from the Austrian Science Fund ( P26728 and F4605 ) and from HVD Biotech, Vienna, Austria and Viravaxx, Vienna, Austria. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2021/4

Y1 - 2021/4

KW - Allergens/chemistry

KW - Animals

KW - Basophils/immunology

KW - Bee Venoms/immunology

KW - Cell Line, Tumor

KW - Epitopes/immunology

KW - Glycosylation

KW - Humans

KW - Immunoglobulin E/immunology

KW - Insect Proteins/chemistry

KW - Phospholipases A/chemistry

KW - Proteins/immunology

KW - Rats

KW - Recombinant Proteins/chemistry

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U2 - 10.1016/j.jaci.2020.10.002

DO - 10.1016/j.jaci.2020.10.002

M3 - Journal article

C2 - 33045279

SN - 0091-6749

VL - 147

SP - 1502-1504.e5

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 4

ER -