Evolution and History of Osteoimmunology

Peter Pietschmann, Ursula Föger-Samwald*, Maria Butylina, Wolfgang Sipos

*Korrespondierende:r Autor:in für diese Arbeit

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Übersichtsartikel

2 Zitate (Scopus)

Abstract

This narrative review focuses on the evolution and history of osteoimmunology, which is a research field that investigates the interactions between bone and components of the immune system. Looking at the evolution of bone, bone development dates back approximately 540 million years. Osteoimmune aspects can also be found in different bone-related diseases like osteoporosis, which is a frequent age-related disease and was first recognized in 1751. Moreover, rheumatoid arthritis is known as the prototype of an osteoimmune disease, which was first clinically described in 1800. A further important component of this field are osteoclasts, a term that was coined by K lliker in 1873. For the treatment of osteoporosis different therapeutic options are available, among which 2 antibodies (denosumab and romosozumab) were currently approved by the European Medicines Agency in 2010 and 2019, respectively, thus showing the importance of osteoimmunological research for patients sake.

OriginalspracheEnglisch
Aufsatznummerosteologie0005-06-2021
Seiten (von - bis)286-291
Seitenumfang6
FachzeitschriftOsteologie
Jahrgang30
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - 01 Nov. 2021
Extern publiziertJa

ASJC Scopus Sachgebiete

  • Allgemeine Medizin

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