TY - JOUR
T1 - Effect of CT imaging on the accuracy of the finite element modelling in bone
AU - Benca, Emir
AU - Amini, Morteza
AU - Pahr, Dieter H
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The finite element (FE) analysis is a highly promising tool to simulate the behaviour of bone. Skeletal FE models in clinical routine rely on the information about the geometry and bone mineral density distribution from quantitative computed tomography (CT) imaging systems. Several parameters in CT imaging have been reported to affect the accuracy of FE models. FE models of bone are exclusively developed in vitro under scanning conditions deviating from the clinical setting, resulting in variability of FE results (< 10%). Slice thickness and field of view had little effect on FE predicted bone behaviour (≤ 4%), while the reconstruction kernels showed to have a larger effect (≤ 20%). Due to large interscanner variations (≤ 20%), the translation from an experimental model into clinical reality is a critical step. Those variations are assumed to be mostly caused by different "black box" reconstruction kernels and the varying frequency of higher density voxels, representing cortical bone. Considering the low number of studies together with the significant effect of CT imaging on the finite element model outcome leading to high variability in the predicted behaviour, we propose further systematic research and validation studies, ideally preceding multicentre and longitudinal studies.
AB - The finite element (FE) analysis is a highly promising tool to simulate the behaviour of bone. Skeletal FE models in clinical routine rely on the information about the geometry and bone mineral density distribution from quantitative computed tomography (CT) imaging systems. Several parameters in CT imaging have been reported to affect the accuracy of FE models. FE models of bone are exclusively developed in vitro under scanning conditions deviating from the clinical setting, resulting in variability of FE results (< 10%). Slice thickness and field of view had little effect on FE predicted bone behaviour (≤ 4%), while the reconstruction kernels showed to have a larger effect (≤ 20%). Due to large interscanner variations (≤ 20%), the translation from an experimental model into clinical reality is a critical step. Those variations are assumed to be mostly caused by different "black box" reconstruction kernels and the varying frequency of higher density voxels, representing cortical bone. Considering the low number of studies together with the significant effect of CT imaging on the finite element model outcome leading to high variability in the predicted behaviour, we propose further systematic research and validation studies, ideally preceding multicentre and longitudinal studies.
KW - Bone Density
KW - Bone Diseases/diagnostic imaging
KW - Bone and Bones/diagnostic imaging
KW - Datasets as Topic
KW - Finite Element Analysis
KW - Humans
KW - Radiographic Image Interpretation, Computer-Assisted/methods
KW - Tomography, X-Ray Computed
UR - http://www.scopus.com/inward/record.url?scp=85090006156&partnerID=8YFLogxK
U2 - 10.1186/s41747-020-00180-3
DO - 10.1186/s41747-020-00180-3
M3 - Journal article
C2 - 32869123
SN - 2509-9280
VL - 4
SP - 51
JO - European radiology experimental
JF - European radiology experimental
IS - 1
M1 - 51
ER -