Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases

Nguyen-Son Le; Stefan Janik; David T Liu; Stefan Grasl; Muhammad Faisal; Johannes Pammer; Bettina Schickinger-Fischer; Jafar-Sasan Hamzavi; Rudolf Seemann; Boban M Erovic

doi:10.1002/hed.26178

Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases

Nguyen-Son Le, Stefan Janik, David T Liu, Stefan Grasl, Muhammad Faisal, Johannes Pammer, Bettina Schickinger-Fischer, Jafar-Sasan Hamzavi, Rudolf Seemann, Boban M Erovic

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Übersichtsartikel

29 Zitate (Scopus)

Abstract

BACKGROUND: The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck.

METHODS: One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta-analysis.

RESULTS: At an average follow up of 20.48 months, the 3-year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3-year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors.

CONCLUSION: Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease-free survival. Due to the high probability of recurrence, close follow-ups are strongly recommended.

Originalsprache	Englisch
Seiten (von - bis)	2644-2659
Seitenumfang	16
Fachzeitschrift	Head and Neck
Jahrgang	42
Ausgabenummer	9
DOIs	https://doi.org/10.1002/hed.26178
Publikationsstatus	Veröffentlicht - Sept. 2020
Extern publiziert	Ja

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10.1002/hed.26178

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title = "Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases",

abstract = "BACKGROUND: The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck.METHODS: One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta-analysis.RESULTS: At an average follow up of 20.48 months, the 3-year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3-year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors.CONCLUSION: Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease-free survival. Due to the high probability of recurrence, close follow-ups are strongly recommended.",

keywords = "Eccrine Porocarcinoma/surgery, Head, Humans, Mohs Surgery, Neoplasm Recurrence, Local, Sweat Gland Neoplasms/surgery",

author = "Nguyen-Son Le and Stefan Janik and Liu, {David T} and Stefan Grasl and Muhammad Faisal and Johannes Pammer and Bettina Schickinger-Fischer and Jafar-Sasan Hamzavi and Rudolf Seemann and Erovic, {Boban M}",

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year = "2020",

month = sep,

doi = "10.1002/hed.26178",

language = "English",

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T1 - Eccrine porocarcinoma of the head and neck

T2 - Meta-analysis of 120 cases

AU - Le, Nguyen-Son

AU - Janik, Stefan

AU - Liu, David T

AU - Grasl, Stefan

AU - Faisal, Muhammad

AU - Pammer, Johannes

AU - Schickinger-Fischer, Bettina

AU - Hamzavi, Jafar-Sasan

AU - Seemann, Rudolf

AU - Erovic, Boban M

PY - 2020/9

Y1 - 2020/9

N2 - BACKGROUND: The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck.METHODS: One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta-analysis.RESULTS: At an average follow up of 20.48 months, the 3-year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3-year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors.CONCLUSION: Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease-free survival. Due to the high probability of recurrence, close follow-ups are strongly recommended.

AB - BACKGROUND: The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck.METHODS: One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta-analysis.RESULTS: At an average follow up of 20.48 months, the 3-year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3-year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors.CONCLUSION: Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease-free survival. Due to the high probability of recurrence, close follow-ups are strongly recommended.

KW - Eccrine Porocarcinoma/surgery

KW - Head

KW - Humans

KW - Mohs Surgery

KW - Neoplasm Recurrence, Local

KW - Sweat Gland Neoplasms/surgery

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U2 - 10.1002/hed.26178

DO - 10.1002/hed.26178

M3 - Review article

C2 - 32314845

SN - 1043-3074

VL - 42

SP - 2644

EP - 2659

JO - Head and Neck

JF - Head and Neck

IS - 9

ER -

Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases

Abstract

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