EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old

Ioana Agache; Cezmi A Akdis; Mubeccel Akdis; Knut Brockow; Tomas Chivato; Stefano Del Giacco; Thomas Eiwegger; Kilian Eyerich; Ana Giménez-Arnau; Jan Gutermuth; Emma Guttman-Yassky; Marcus Maurer; Graham Ogg; Peck Y Ong; Liam O'Mahony; Jürgen Schwarze; Amena Warner; Thomas Werfel; Oscar Palomares; Marek Jutel

doi:10.1111/all.15030

EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old

Ioana Agache, Cezmi A Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano Del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Giménez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y Ong, Liam O'Mahony, Jürgen Schwarze, Amena Warner, Thomas Werfel, Oscar Palomares, Marek Jutel

Klinische Abteilung für Kinder- und Jugendheilkunde (Universitätsklinikum St. Pölten)

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

32 Zitate (Scopus)

Abstract

Chronic spontaneous urticaria (CSU) imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity and insufficient efficacy of classical drugs such as H1 R-antihistamines. Better understanding of the mechanisms has enabled a stratified approach to the management of CSU, supporting the use of targeted treatment with omalizumab. However, many practical issues including selection of responders, the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home-based) and its cost-effectiveness still require further clarification. The EAACI Guidelines on the use of omalizumab in CSU follow the GRADE approach in formulating recommendations for each outcome. In addition, future therapeutic approaches and perspectives as well as research priorities are discussed.

Originalsprache	Englisch
Seiten (von - bis)	17-38
Seitenumfang	22
Fachzeitschrift	Allergy: European Journal of Allergy and Clinical Immunology
Jahrgang	77
Ausgabenummer	1
DOIs	https://doi.org/10.1111/all.15030
Publikationsstatus	Veröffentlicht - Jan. 2022

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10.1111/all.15030

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Agache, I., Akdis, C. A., Akdis, M., Brockow, K., Chivato, T., Del Giacco, S., Eiwegger, T., Eyerich, K., Giménez-Arnau, A., Gutermuth, J., Guttman-Yassky, E., Maurer, M., Ogg, G., Ong, P. Y., O'Mahony, L., Schwarze, J., Warner, A., Werfel, T., Palomares, O., & Jutel, M. (2022). EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old. Allergy: European Journal of Allergy and Clinical Immunology, 77(1), 17-38. https://doi.org/10.1111/all.15030

@article{0aff69bb314b44deb3065d445bc38fae,

title = "EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old",

abstract = "Chronic spontaneous urticaria (CSU) imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity and insufficient efficacy of classical drugs such as H1 R-antihistamines. Better understanding of the mechanisms has enabled a stratified approach to the management of CSU, supporting the use of targeted treatment with omalizumab. However, many practical issues including selection of responders, the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home-based) and its cost-effectiveness still require further clarification. The EAACI Guidelines on the use of omalizumab in CSU follow the GRADE approach in formulating recommendations for each outcome. In addition, future therapeutic approaches and perspectives as well as research priorities are discussed.",

keywords = "Adolescent, Adult, Anti-Allergic Agents/therapeutic use, Biological Products/therapeutic use, Child, Chronic Disease, Chronic Urticaria, Humans, Omalizumab/therapeutic use, Treatment Outcome, Urticaria/drug therapy",

author = "Ioana Agache and Akdis, {Cezmi A} and Mubeccel Akdis and Knut Brockow and Tomas Chivato and {Del Giacco}, Stefano and Thomas Eiwegger and Kilian Eyerich and Ana Gim{\'e}nez-Arnau and Jan Gutermuth and Emma Guttman-Yassky and Marcus Maurer and Graham Ogg and Ong, {Peck Y} and Liam O'Mahony and J{\"u}rgen Schwarze and Amena Warner and Thomas Werfel and Oscar Palomares and Marek Jutel",

note = "Publisher Copyright: {\textcopyright} 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.",

year = "2022",

month = jan,

doi = "10.1111/all.15030",

language = "English",

volume = "77",

pages = "17--38",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

Agache, I, Akdis, CA, Akdis, M, Brockow, K, Chivato, T, Del Giacco, S, Eiwegger, T, Eyerich, K, Giménez-Arnau, A, Gutermuth, J, Guttman-Yassky, E, Maurer, M, Ogg, G, Ong, PY, O'Mahony, L, Schwarze, J, Warner, A, Werfel, T, Palomares, O & Jutel, M 2022, 'EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old', Allergy: European Journal of Allergy and Clinical Immunology, Jg. 77, Nr. 1, S. 17-38. https://doi.org/10.1111/all.15030

EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old. / Agache, Ioana; Akdis, Cezmi A; Akdis, Mubeccel et al.
in: Allergy: European Journal of Allergy and Clinical Immunology, Jahrgang 77, Nr. 1, 01.2022, S. 17-38.

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

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T1 - EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old

AU - Agache, Ioana

AU - Akdis, Cezmi A

AU - Akdis, Mubeccel

AU - Brockow, Knut

AU - Chivato, Tomas

AU - Del Giacco, Stefano

AU - Eiwegger, Thomas

AU - Eyerich, Kilian

AU - Giménez-Arnau, Ana

AU - Gutermuth, Jan

AU - Guttman-Yassky, Emma

AU - Maurer, Marcus

AU - Ogg, Graham

AU - Ong, Peck Y

AU - O'Mahony, Liam

AU - Schwarze, Jürgen

AU - Warner, Amena

AU - Werfel, Thomas

AU - Palomares, Oscar

AU - Jutel, Marek

PY - 2022/1

Y1 - 2022/1

N2 - Chronic spontaneous urticaria (CSU) imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity and insufficient efficacy of classical drugs such as H1 R-antihistamines. Better understanding of the mechanisms has enabled a stratified approach to the management of CSU, supporting the use of targeted treatment with omalizumab. However, many practical issues including selection of responders, the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home-based) and its cost-effectiveness still require further clarification. The EAACI Guidelines on the use of omalizumab in CSU follow the GRADE approach in formulating recommendations for each outcome. In addition, future therapeutic approaches and perspectives as well as research priorities are discussed.

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KW - Adult

KW - Anti-Allergic Agents/therapeutic use

KW - Biological Products/therapeutic use

KW - Child

KW - Chronic Disease

KW - Chronic Urticaria

KW - Humans

KW - Omalizumab/therapeutic use

KW - Treatment Outcome

KW - Urticaria/drug therapy

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U2 - 10.1111/all.15030

DO - 10.1111/all.15030

M3 - Journal article

C2 - 34324716

SN - 0105-4538

VL - 77

SP - 17

EP - 38

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 1

ER -

EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old

Abstract

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