Cytokines and signal transduction

Teru Hideshima, Klaus Podar, Dharminder Chauhan, Kenneth C Anderson

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Übersichtsartikel

97 Zitate (Scopus)

Abstract

Many studies have characterized the role of growth factors in multiple myeloma (MM) pathogenesis and have derived novel therapies to improve patient outcome based upon targeting cytokines and their signaling cascades both in the MM cell and in the bone-marrow (BM) microenvironment. These cytokines include interleukin 6 (IL-6), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), transforming growth factor β (TGF-β), stromal cell-derived factor 1α (SDF-1α), IL-21, B-cell stimulating factor 3 (BSF-3) and fibroblast growth factor (FGF). These cytokines are secreted from stromal cells (SCs), endothelial cells and/or osteoclasts, and promote MM cell growth, survival and migration, as well as paracrine cytokine secretion and angiogenesis in the BM milieu. Thus inhibition of signaling cascades induced by these cytokine provides rationale for a therapeutic option for MM.

OriginalspracheEnglisch
Seiten (von - bis)509-524
Seitenumfang16
FachzeitschriftBest Practice and Research in Clinical Haematology
Jahrgang18
Ausgabenummer4 SPEC. ISS.
DOIs
PublikationsstatusVeröffentlicht - Dez. 2005
Extern publiziertJa

ASJC Scopus Sachgebiete

  • Onkologie
  • Klinische Biochemie

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