@article{a70c5d6c04554bf7b5233f85a8873a23,
title = "Cut stroke in half: Polypill for primary prevention in stroke",
abstract = "This review summarizes the potential for polypill therapies for stroke prevention. While a number of studies applying different approaches regarding polypill have been performed, none of them has had a focus on stroke as the main outcome. A combination pill containing drugs such as statins, diuretics, and other antihypertensives is currently available in various formats. Estimates focusing mostly on primary prevention show that using such a combination drug a reduction in the 5-year stroke incidence by 50% can be achieved - especially in low- and middle-income countries with a high prevalence of risk factors even among people at young ages. A combination of a large supporting population-wide program with a registry-based quality control is the most likely perspective and can be achieved within a reasonable time frame and potentially have significant influence in young stroke populations.",
keywords = "Cardiovascular Agents/therapeutic use, Drug Combinations, Humans, Medication Adherence, Polypharmacy, Population Groups, Primary Prevention, Randomized Controlled Trials as Topic, Risk Factors, Stroke/drug therapy",
author = "Michael Brainin and Valery Feigin and Sheila Martins and Karl Matz and Jayanta Roy and Peter Sandercock and Yvonne Teuschl and Jaakko Tuomilehto and Anita Wiseman",
note = "Funding Information: 1Department for Clinical Neuroscience and Preventive Medicine, Danube University Krems, Krems, Austria 2National Institute for Stroke and Applied Neurosciences, Auckland University of Technology, School of Public Health and Psychosocial Studies, Auckland, New Zealand 3Neurology and Neurosurgery Service, Hospital Moinhos de Vento, Brazil 4Department of Neurology, University Hospital Tulln, Tulln, Austria 5AMRI Institute of Neurosciences, Kolkata, India 6Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK 7Dasman Diabetes Institute, Kuwait City, Kuwait 8Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland 9Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia 10World Stroke Organisation, Geneva, Switzerland Publisher Copyright: {\textcopyright} 2018 World Stroke Organization.",
year = "2018",
month = aug,
day = "1",
doi = "10.1177/1747493018761190",
language = "English",
volume = "13",
pages = "633--647",
journal = "International Journal of Stroke",
issn = "1747-4930",
publisher = "SAGE Publications Ltd",
number = "6",
}