TY - JOUR
T1 - Circulating Myostatin Levels Decrease Transiently after Implantation of a Hip Hemi-Arthroplasty
AU - Kerschan-Schindl, Katharina
AU - Tiefenböck, Thomas M
AU - Föger-Samwald, Ursula
AU - Payr, Stephan
AU - Frenzel, Stephan
AU - Marculescu, Rodrig
AU - Gleiss, Andreas
AU - Sarahrudi, Kambiz
AU - Pietschmann, Peter
N1 - Publisher Copyright:
© 2020
PY - 2020/7/1
Y1 - 2020/7/1
N2 - INTRODUCTION: Muscle and bone metabolism are both important for the healing of fractures and the regeneration of injured muscle tissue. The aim of this investigation was to evaluate myostatin and other regulating factors in patients with hip fractures who underwent hemi-arthroplasty.METHODS: Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf-1 (Dkk1), and periostin (PSTN) as well as markers of bone turnover were evaluated in patients with hip fractures before surgery and twice in the 2 weeks after surgery. These parameters were also evaluated in age- and gender-matched subjects without major musculoskeletal injury.RESULTS: MSTN was transiently reduced; its opponent FSTN was transiently increased. Dkk1, the negative regulator of bone mass, and PSTN, a marker of subperiosteal bone formation, increased after surgery. With regard to markers of bone turnover, resorption was elevated during the entire period of observation whereas the early bone formation marker N-terminal propeptide of type I collagen was elevated 12 days after surgery.CONCLUSIONS: Unexpectedly, MSTN, a negative regulator of muscle growth, was reduced after surgery compared with before surgery. As musculoskeletal markers are altered during bone healing, they do not reflect general bone metabolism after fracture or joint arthroplasty. This is important because many elderly patients receive treatment for osteoporosis.
AB - INTRODUCTION: Muscle and bone metabolism are both important for the healing of fractures and the regeneration of injured muscle tissue. The aim of this investigation was to evaluate myostatin and other regulating factors in patients with hip fractures who underwent hemi-arthroplasty.METHODS: Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf-1 (Dkk1), and periostin (PSTN) as well as markers of bone turnover were evaluated in patients with hip fractures before surgery and twice in the 2 weeks after surgery. These parameters were also evaluated in age- and gender-matched subjects without major musculoskeletal injury.RESULTS: MSTN was transiently reduced; its opponent FSTN was transiently increased. Dkk1, the negative regulator of bone mass, and PSTN, a marker of subperiosteal bone formation, increased after surgery. With regard to markers of bone turnover, resorption was elevated during the entire period of observation whereas the early bone formation marker N-terminal propeptide of type I collagen was elevated 12 days after surgery.CONCLUSIONS: Unexpectedly, MSTN, a negative regulator of muscle growth, was reduced after surgery compared with before surgery. As musculoskeletal markers are altered during bone healing, they do not reflect general bone metabolism after fracture or joint arthroplasty. This is important because many elderly patients receive treatment for osteoporosis.
KW - Aged
KW - Aged, 80 and over
KW - Arthroplasty, Replacement, Hip
KW - Austria
KW - Biomarkers/blood
KW - Bone Morphogenetic Proteins/blood
KW - Bone Remodeling/physiology
KW - Case-Control Studies
KW - Cell Adhesion Molecules/blood
KW - Female
KW - Follistatin/blood
KW - Hemiarthroplasty
KW - Hip Fractures/blood
KW - Humans
KW - Intercellular Signaling Peptides and Proteins/blood
KW - Myostatin/blood
KW - Osteogenesis/physiology
KW - Prospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85088678456&partnerID=8YFLogxK
U2 - 10.1159/000507731
DO - 10.1159/000507731
M3 - Journal article
C2 - 32454508
SN - 0304-324X
VL - 66
SP - 393
EP - 400
JO - Gerontology
JF - Gerontology
IS - 4
ER -