Caveolin-1 as a potential new therapeutic target in multiple myeloma

Klaus Podar; Kenneth C Anderson

doi:10.1016/j.canlet.2005.02.035

Caveolin-1 as a potential new therapeutic target in multiple myeloma

Klaus Podar
, Kenneth C Anderson

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Übersichtsartikel

28 Zitate (Scopus)

Abstract

Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.

Originalsprache	Englisch
Seiten (von - bis)	10-15
Seitenumfang	6
Fachzeitschrift	Cancer Letters
Jahrgang	233
Ausgabenummer	1
DOIs	https://doi.org/10.1016/j.canlet.2005.02.035
Publikationsstatus	Veröffentlicht - 20 Feb. 2006
Extern publiziert	Ja

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title = "Caveolin-1 as a potential new therapeutic target in multiple myeloma",

abstract = "Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.",

keywords = "Animals, Caveolae/chemistry, Caveolin 1/antagonists \& inhibitors, Cholesterol/biosynthesis, Drug Delivery Systems, Humans, Multiple Myeloma/drug therapy, Phosphatidylinositol 3-Kinases/physiology, Vascular Endothelial Growth Factor A/physiology",

author = "Klaus Podar and Anderson, \{Kenneth C\}",

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doi = "10.1016/j.canlet.2005.02.035",

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T1 - Caveolin-1 as a potential new therapeutic target in multiple myeloma

AU - Podar, Klaus

AU - Anderson, Kenneth C

PY - 2006/2/20

Y1 - 2006/2/20

N2 - Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.

AB - Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.

KW - Animals

KW - Caveolae/chemistry

KW - Caveolin 1/antagonists & inhibitors

KW - Cholesterol/biosynthesis

KW - Drug Delivery Systems

KW - Humans

KW - Multiple Myeloma/drug therapy

KW - Phosphatidylinositol 3-Kinases/physiology

KW - Vascular Endothelial Growth Factor A/physiology

UR - https://www.scopus.com/pages/publications/32244434747

U2 - 10.1016/j.canlet.2005.02.035

DO - 10.1016/j.canlet.2005.02.035

M3 - Review article

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VL - 233

SP - 10

EP - 15

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Caveolin-1 as a potential new therapeutic target in multiple myeloma

Abstract

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