TY - JOUR
T1 - Caveolin-1 as a potential new therapeutic target in multiple myeloma
AU - Podar, Klaus
AU - Anderson, Kenneth C
PY - 2006/2/20
Y1 - 2006/2/20
N2 - Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.
AB - Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.
KW - Animals
KW - Caveolae/chemistry
KW - Caveolin 1/antagonists & inhibitors
KW - Cholesterol/biosynthesis
KW - Drug Delivery Systems
KW - Humans
KW - Multiple Myeloma/drug therapy
KW - Phosphatidylinositol 3-Kinases/physiology
KW - Vascular Endothelial Growth Factor A/physiology
UR - http://www.scopus.com/inward/record.url?scp=32244434747&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2005.02.035
DO - 10.1016/j.canlet.2005.02.035
M3 - Review article
C2 - 16473666
SN - 0304-3835
VL - 233
SP - 10
EP - 15
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -