Bilateral vs ipsilateral adjuvant radiotherapy in patients with cancer of unknown primary of the head and neck: An analysis of the clinical outcome and radiation-induced side effects

Nguyen-Son Le; Stefan Janik; Helmut Simmel; Boban M Erovic

doi:10.1002/hed.25637

Bilateral vs ipsilateral adjuvant radiotherapy in patients with cancer of unknown primary of the head and neck: An analysis of the clinical outcome and radiation-induced side effects

Nguyen-Son Le
, Stefan Janik
, Helmut Simmel
, Boban M Erovic

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

12 Zitate (Scopus)

Abstract

BACKGROUND: The purpose of this study was to analyze and compare ipsilateral and bilateral adjuvant radiotherapy in patients with cancer of unknown primary (CUP) of the head and neck.

METHODS: Overall survival, recurrence-free survival, and radiation-induced side effects were assessed in 76 patients with CUP who underwent ipsilateral (n = 29) or bilateral (n = 47) radiotherapy.

RESULTS: At a median follow-up of 41 months, the 5-year overall survival and recurrence-free rate were 67.9% and 71.5%, respectively. No statistically significant difference between ipsilateral and bilateral radiotherapy could be found regarding 5-year overall survival, recurrence-free survival, occurrence of a primary tumor, and distant metastasis. The analysis of radiation-induced acute side effects showed a significant benefit of ipsilateral radiotherapy.

CONCLUSION: As the main parameters of the study regarding the outcome and radiation-induced side effects showed no advantages of bilateral radiotherapy, the strategy of ipsilateral radiotherapy can be recommended for the adjuvant treatment of CUP patients.

Originalsprache	Englisch
Seiten (von - bis)	1785-1794
Seitenumfang	10
Fachzeitschrift	Head and Neck
Jahrgang	41
Ausgabenummer	6
DOIs	https://doi.org/10.1002/hed.25637
Publikationsstatus	Veröffentlicht - Juni 2019
Extern publiziert	Ja

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@article{79c25a96709a4879958a5e3439d9d639,

title = "Bilateral vs ipsilateral adjuvant radiotherapy in patients with cancer of unknown primary of the head and neck: An analysis of the clinical outcome and radiation-induced side effects",

abstract = "BACKGROUND: The purpose of this study was to analyze and compare ipsilateral and bilateral adjuvant radiotherapy in patients with cancer of unknown primary (CUP) of the head and neck.METHODS: Overall survival, recurrence-free survival, and radiation-induced side effects were assessed in 76 patients with CUP who underwent ipsilateral (n = 29) or bilateral (n = 47) radiotherapy.RESULTS: At a median follow-up of 41 months, the 5-year overall survival and recurrence-free rate were 67.9\% and 71.5\%, respectively. No statistically significant difference between ipsilateral and bilateral radiotherapy could be found regarding 5-year overall survival, recurrence-free survival, occurrence of a primary tumor, and distant metastasis. The analysis of radiation-induced acute side effects showed a significant benefit of ipsilateral radiotherapy.CONCLUSION: As the main parameters of the study regarding the outcome and radiation-induced side effects showed no advantages of bilateral radiotherapy, the strategy of ipsilateral radiotherapy can be recommended for the adjuvant treatment of CUP patients.",

keywords = "Carcinoma/mortality, Cohort Studies, Female, Head and Neck Neoplasms/mortality, Humans, Male, Middle Aged, Neoplasms, Unknown Primary/mortality, Radiotherapy, Adjuvant, Survival Rate, Treatment Outcome",

author = "Nguyen-Son Le and Stefan Janik and Helmut Simmel and Erovic, \{Boban M\}",

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year = "2019",

month = jun,

doi = "10.1002/hed.25637",

language = "English",

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journal = "Head and Neck",

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Bilateral vs ipsilateral adjuvant radiotherapy in patients with cancer of unknown primary of the head and neck: An analysis of the clinical outcome and radiation-induced side effects. / Le, Nguyen-Son; Janik, Stefan; Simmel, Helmut et al.
in: Head and Neck, Jahrgang 41, Nr. 6, 06.2019, S. 1785-1794.

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

TY - JOUR

T1 - Bilateral vs ipsilateral adjuvant radiotherapy in patients with cancer of unknown primary of the head and neck

T2 - An analysis of the clinical outcome and radiation-induced side effects

AU - Le, Nguyen-Son

AU - Janik, Stefan

AU - Simmel, Helmut

AU - Erovic, Boban M

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: The purpose of this study was to analyze and compare ipsilateral and bilateral adjuvant radiotherapy in patients with cancer of unknown primary (CUP) of the head and neck.METHODS: Overall survival, recurrence-free survival, and radiation-induced side effects were assessed in 76 patients with CUP who underwent ipsilateral (n = 29) or bilateral (n = 47) radiotherapy.RESULTS: At a median follow-up of 41 months, the 5-year overall survival and recurrence-free rate were 67.9% and 71.5%, respectively. No statistically significant difference between ipsilateral and bilateral radiotherapy could be found regarding 5-year overall survival, recurrence-free survival, occurrence of a primary tumor, and distant metastasis. The analysis of radiation-induced acute side effects showed a significant benefit of ipsilateral radiotherapy.CONCLUSION: As the main parameters of the study regarding the outcome and radiation-induced side effects showed no advantages of bilateral radiotherapy, the strategy of ipsilateral radiotherapy can be recommended for the adjuvant treatment of CUP patients.

AB - BACKGROUND: The purpose of this study was to analyze and compare ipsilateral and bilateral adjuvant radiotherapy in patients with cancer of unknown primary (CUP) of the head and neck.METHODS: Overall survival, recurrence-free survival, and radiation-induced side effects were assessed in 76 patients with CUP who underwent ipsilateral (n = 29) or bilateral (n = 47) radiotherapy.RESULTS: At a median follow-up of 41 months, the 5-year overall survival and recurrence-free rate were 67.9% and 71.5%, respectively. No statistically significant difference between ipsilateral and bilateral radiotherapy could be found regarding 5-year overall survival, recurrence-free survival, occurrence of a primary tumor, and distant metastasis. The analysis of radiation-induced acute side effects showed a significant benefit of ipsilateral radiotherapy.CONCLUSION: As the main parameters of the study regarding the outcome and radiation-induced side effects showed no advantages of bilateral radiotherapy, the strategy of ipsilateral radiotherapy can be recommended for the adjuvant treatment of CUP patients.

KW - Carcinoma/mortality

KW - Cohort Studies

KW - Female

KW - Head and Neck Neoplasms/mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms, Unknown Primary/mortality

KW - Radiotherapy, Adjuvant

KW - Survival Rate

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/85060352064

U2 - 10.1002/hed.25637

DO - 10.1002/hed.25637

M3 - Journal article

C2 - 30659688

SN - 1043-3074

VL - 41

SP - 1785

EP - 1794

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -