An update on recent developments and highlights in food allergy

Arielle Locke, Lisa Hung, Julia E M Upton, Liam O'Mahony, Jennifer Hoang, Thomas Eiwegger

Publikation: Beitrag in Fachzeitschrift (peer-reviewed)Übersichtsartikel

3 Zitate (Scopus)

Abstract

While both the incidence and general awareness of food allergies is increasing, the variety and clinical availability of therapeutics remain limited. Therefore, investigations into the potential factors contributing to the development of food allergy and the mechanisms of natural tolerance or induced desensitization are required. In addition, a detailed understanding of the pathophysiology of food allergies is needed to generate compelling, enduring, and safe treatment options. New findings regarding the contribution of barrier function, the effect of emollient interventions, mechanisms of allergen recognition, and the contributions of specific immune cell subsets through rodent models and human clinical studies provide novel insights. With the first approved treatment for peanut allergy, the clinical management of food allergy is evolving towards less intensive, alternative approaches involving fixed doses, lower maintenance dose targets, co-administration of biologicals, adjuvants, and tolerance-inducing formulations. The ultimate goal is to improve immunotherapy and develop precision-based medicine via risk phenotyping allowing optimal treatment for each food-allergic patient.

OriginalspracheEnglisch
Seiten (von - bis)2344-2360
Seitenumfang17
FachzeitschriftAllergy: European Journal of Allergy and Clinical Immunology
Jahrgang78
Ausgabenummer9
Frühes Online-Datum23 Apr. 2023
DOIs
PublikationsstatusVeröffentlicht - Sept. 2023

ASJC Scopus Sachgebiete

  • Immunologie und Allergologie
  • Immunologie

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