TY - JOUR
T1 - An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients
AU - Scheichel, Florian
AU - Pinggera, Daniel
AU - Popadic, Branko
AU - Sherif, Camillo
AU - Marhold, Franz
AU - Freyschlag, Christian Franz
N1 - Publisher Copyright:
Copyright © 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag.
PY - 2022/4/20
Y1 - 2022/4/20
N2 - Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients.
AB - Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients.
UR - http://www.scopus.com/inward/record.url?scp=85129502768&partnerID=8YFLogxK
U2 - 10.3389/fonc.2022.884724
DO - 10.3389/fonc.2022.884724
M3 - Review article
C2 - 35515113
SN - 2234-943X
VL - 12
SP - 884724
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 884724
ER -