Adverse fetal/neonatal and obstetric outcomes in pregnancies with both maternal and fetal heart disease

Beatriz A Fernandez-Campos; Jasmine Grewal; Marla Kiess; Samuel C Siu; Birgit Pfaller; Mathew Sermer; Jennifer Mason; Candice K Silversides; Kim Haberer

doi:10.1038/s41372-024-02058-3

Adverse fetal/neonatal and obstetric outcomes in pregnancies with both maternal and fetal heart disease

Beatriz A Fernandez-Campos, Jasmine Grewal, Marla Kiess, Samuel C Siu, Birgit Pfaller, Mathew Sermer, Jennifer Mason, Candice K Silversides, Kim Haberer

Klinische Abteilung für Innere Medizin I (UK St. Pölten)

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

Abstract

OBJECTIVE: To investigate fetal/neonatal and obstetric events in pregnancies with both maternal and fetal heart disease.

STUDY DESIGN: From the CARPREG database, singleton pregnancies (>24 weeks) in patients with structural heart disease that underwent fetal/neonatal echocardiograms were selected and separated in two groups: maternal heart disease only (M-HD) and maternal and fetal heart disease (MF-HD). Differences in adverse fetal/neonatal (death, preterm birth, and small for gestational age) and obstetric (preeclampsia/eclampsia) outcomes between groups were analyzed.

RESULTS: From 1011 pregnancies, 93 had MF-HD. Fetal/neonatal events (38.7% vs 25.3%, p = 0.006) and spontaneous preterm birth (10.8% vs 4.9%, p = 0.021) were more frequent in MF-HD compared to M-HD, with no difference in obstetric events. MF-HD remained as a significant predictor of fetal/neonatal events after adjustment (OR:1.883; 95% CI:1.182-3.000; p = 0.008).

CONCLUSIONS: Pregnancies with MF-HD are at risk of adverse fetal/neonatal events and spontaneous preterm birth. Larger studies are needed to determine their association with preeclampsia.

Originalsprache	Englisch
Seiten (von - bis)	1424-1431
Seitenumfang	8
Fachzeitschrift	Journal of Perinatology
Jahrgang	44
Ausgabenummer	10
Frühes Online-Datum	23 Juli 2024
DOIs	https://doi.org/10.1038/s41372-024-02058-3
Publikationsstatus	Veröffentlicht - Okt. 2024

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10.1038/s41372-024-02058-3

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1 Abgeschlossen
1 Laufend

PreCareCGM: Untersuchung des Blutzuckerspiegels nach der Geburt bei Frauen mit Präeklampsie/ Bluthochdruckerkrankung in der Schwangerschaft und/oder Adipositas mit einem langfristig erhöhten Risiko für einen Diabetes Typ 2 – Pilotstudie
Pfaller-Eiwegger, B. (PI)
Forschungsimpulse
01.01.2024 → 31.12.2026
Projekt: Forschungsimpulse › Forschungsfreiraum (RTO)
Evaluierung der postpartalen Versorgung von Frauen mit Präeklampsie und Schwangerschaftsdiabetes in Niederösterreich
Pfaller-Eiwegger, B. (PI)
Forschungsimpulse
01.02.2021 → 31.01.2025
Projekt: Forschungsimpulse › Seed Funding

Dieses zitieren

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abstract = "OBJECTIVE: To investigate fetal/neonatal and obstetric events in pregnancies with both maternal and fetal heart disease.STUDY DESIGN: From the CARPREG database, singleton pregnancies (>24 weeks) in patients with structural heart disease that underwent fetal/neonatal echocardiograms were selected and separated in two groups: maternal heart disease only (M-HD) and maternal and fetal heart disease (MF-HD). Differences in adverse fetal/neonatal (death, preterm birth, and small for gestational age) and obstetric (preeclampsia/eclampsia) outcomes between groups were analyzed.RESULTS: From 1011 pregnancies, 93 had MF-HD. Fetal/neonatal events (38.7% vs 25.3%, p = 0.006) and spontaneous preterm birth (10.8% vs 4.9%, p = 0.021) were more frequent in MF-HD compared to M-HD, with no difference in obstetric events. MF-HD remained as a significant predictor of fetal/neonatal events after adjustment (OR:1.883; 95% CI:1.182-3.000; p = 0.008).CONCLUSIONS: Pregnancies with MF-HD are at risk of adverse fetal/neonatal events and spontaneous preterm birth. Larger studies are needed to determine their association with preeclampsia.",

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author = "Fernandez-Campos, {Beatriz A} and Jasmine Grewal and Marla Kiess and Siu, {Samuel C} and Birgit Pfaller and Mathew Sermer and Jennifer Mason and Silversides, {Candice K} and Kim Haberer",

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AU - Fernandez-Campos, Beatriz A

AU - Grewal, Jasmine

AU - Kiess, Marla

AU - Siu, Samuel C

AU - Pfaller, Birgit

AU - Sermer, Mathew

AU - Mason, Jennifer

AU - Silversides, Candice K

AU - Haberer, Kim

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/10

Y1 - 2024/10

N2 - OBJECTIVE: To investigate fetal/neonatal and obstetric events in pregnancies with both maternal and fetal heart disease.STUDY DESIGN: From the CARPREG database, singleton pregnancies (>24 weeks) in patients with structural heart disease that underwent fetal/neonatal echocardiograms were selected and separated in two groups: maternal heart disease only (M-HD) and maternal and fetal heart disease (MF-HD). Differences in adverse fetal/neonatal (death, preterm birth, and small for gestational age) and obstetric (preeclampsia/eclampsia) outcomes between groups were analyzed.RESULTS: From 1011 pregnancies, 93 had MF-HD. Fetal/neonatal events (38.7% vs 25.3%, p = 0.006) and spontaneous preterm birth (10.8% vs 4.9%, p = 0.021) were more frequent in MF-HD compared to M-HD, with no difference in obstetric events. MF-HD remained as a significant predictor of fetal/neonatal events after adjustment (OR:1.883; 95% CI:1.182-3.000; p = 0.008).CONCLUSIONS: Pregnancies with MF-HD are at risk of adverse fetal/neonatal events and spontaneous preterm birth. Larger studies are needed to determine their association with preeclampsia.

AB - OBJECTIVE: To investigate fetal/neonatal and obstetric events in pregnancies with both maternal and fetal heart disease.STUDY DESIGN: From the CARPREG database, singleton pregnancies (>24 weeks) in patients with structural heart disease that underwent fetal/neonatal echocardiograms were selected and separated in two groups: maternal heart disease only (M-HD) and maternal and fetal heart disease (MF-HD). Differences in adverse fetal/neonatal (death, preterm birth, and small for gestational age) and obstetric (preeclampsia/eclampsia) outcomes between groups were analyzed.RESULTS: From 1011 pregnancies, 93 had MF-HD. Fetal/neonatal events (38.7% vs 25.3%, p = 0.006) and spontaneous preterm birth (10.8% vs 4.9%, p = 0.021) were more frequent in MF-HD compared to M-HD, with no difference in obstetric events. MF-HD remained as a significant predictor of fetal/neonatal events after adjustment (OR:1.883; 95% CI:1.182-3.000; p = 0.008).CONCLUSIONS: Pregnancies with MF-HD are at risk of adverse fetal/neonatal events and spontaneous preterm birth. Larger studies are needed to determine their association with preeclampsia.

KW - Pre-Eclampsia/epidemiology

KW - Echocardiography

KW - Humans

KW - Pregnancy Complications, Cardiovascular/epidemiology

KW - Logistic Models

KW - Gestational Age

KW - Pregnancy

KW - Ultrasonography, Prenatal

KW - Heart Diseases

KW - Premature Birth/epidemiology

KW - Female

KW - Adult

KW - Infant, Small for Gestational Age

KW - Retrospective Studies

KW - Infant, Newborn

KW - Pregnancy Outcome

KW - Fetal Diseases/epidemiology

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U2 - 10.1038/s41372-024-02058-3

DO - 10.1038/s41372-024-02058-3

M3 - Journal article

C2 - 39043994

SN - 0743-8346

VL - 44

SP - 1424

EP - 1431

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 10

ER -

Adverse fetal/neonatal and obstetric outcomes in pregnancies with both maternal and fetal heart disease

Abstract

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Projekte

PreCareCGM: Untersuchung des Blutzuckerspiegels nach der Geburt bei Frauen mit Präeklampsie/ Bluthochdruckerkrankung in der Schwangerschaft und/oder Adipositas mit einem langfristig erhöhten Risiko für einen Diabetes Typ 2 – Pilotstudie

Evaluierung der postpartalen Versorgung von Frauen mit Präeklampsie und Schwangerschaftsdiabetes in Niederösterreich

Dieses zitieren