A mouse model to identify cooperating signaling pathways in cancer

Monica Musteanu; Leander Blaas; Rainer Zenz; Jasmin Svinka; Thomas Hoffmann; Beatrice Grabner; Daniel Schramek; Hans-Peter Kantner; Mathias Müller; Thomas Kolbe; Thomas Rülicke; Richard Moriggl; Lukas Kenner; Dagmar Stoiber; Josef Martin Penninger; Helmut Popper; Emilio Casanova; Robert Eferl

doi:10.1038/nmeth.2130

A mouse model to identify cooperating signaling pathways in cancer

Monica Musteanu
, Leander Blaas
, Rainer Zenz
, Jasmin Svinka
, Thomas Hoffmann
, Beatrice Grabner
, Daniel Schramek
, Hans-Peter Kantner
, Mathias Müller
, Thomas Kolbe
, Thomas Rülicke
, Richard Moriggl
, Lukas Kenner
, Dagmar Stoiber
, Josef Martin Penninger
, Helmut Popper
, Emilio Casanova
, Robert Eferl

Publikation: Beitrag in Fachzeitschrift (peer-reviewed) › Artikel in Fachzeitschrift

12 Zitate (Scopus)

Abstract

We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.

Originalsprache	Englisch
Seiten (von - bis)	897-900
Seitenumfang	4
Fachzeitschrift	Nature Methods
Jahrgang	9
Ausgabenummer	9
DOIs	https://doi.org/10.1038/nmeth.2130
Publikationsstatus	Veröffentlicht - Sept. 2012
Extern publiziert	Ja

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Musteanu, M., Blaas, L., Zenz, R., Svinka, J., Hoffmann, T., Grabner, B., Schramek, D., Kantner, H.-P., Müller, M., Kolbe, T., Rülicke, T., Moriggl, R., Kenner, L., Stoiber, D., Penninger, J. M., Popper, H., Casanova, E., & Eferl, R. (2012). A mouse model to identify cooperating signaling pathways in cancer. Nature Methods, 9(9), 897-900. https://doi.org/10.1038/nmeth.2130

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abstract = "We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.",

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T1 - A mouse model to identify cooperating signaling pathways in cancer

AU - Musteanu, Monica

AU - Blaas, Leander

AU - Zenz, Rainer

AU - Svinka, Jasmin

AU - Hoffmann, Thomas

AU - Grabner, Beatrice

AU - Schramek, Daniel

AU - Kantner, Hans-Peter

AU - Müller, Mathias

AU - Kolbe, Thomas

AU - Rülicke, Thomas

AU - Moriggl, Richard

AU - Kenner, Lukas

AU - Stoiber, Dagmar

AU - Penninger, Josef Martin

AU - Popper, Helmut

AU - Casanova, Emilio

AU - Eferl, Robert

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AB - We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.

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KW - Disease Models, Animal

KW - Female

KW - Lung Neoplasms/genetics

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Neoplasms, Experimental/genetics

KW - Oncogene Protein p21(ras)/genetics

KW - Pancreatic Neoplasms/genetics

KW - Signal Transduction/genetics

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DO - 10.1038/nmeth.2130

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VL - 9

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JO - Nature Methods

JF - Nature Methods

IS - 9

ER -

A mouse model to identify cooperating signaling pathways in cancer

Abstract

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