@article{3e5677594d21442cb3d51d11f6649ee8,
title = "A mouse model to identify cooperating signaling pathways in cancer",
abstract = "We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.",
keywords = "Animals, Disease Models, Animal, Female, Lung Neoplasms/genetics, Male, Mice, Mice, Transgenic, Neoplasms, Experimental/genetics, Oncogene Protein p21(ras)/genetics, Pancreatic Neoplasms/genetics, Signal Transduction/genetics",
author = "Monica Musteanu and Leander Blaas and Rainer Zenz and Jasmin Svinka and Thomas Hoffmann and Beatrice Grabner and Daniel Schramek and Hans-Peter Kantner and Mathias M{\"u}ller and Thomas Kolbe and Thomas R{\"u}licke and Richard Moriggl and Lukas Kenner and Dagmar Stoiber and Penninger, {Josef Martin} and Helmut Popper and Emilio Casanova and Robert Eferl",
year = "2012",
month = sep,
doi = "10.1038/nmeth.2130",
language = "English",
volume = "9",
pages = "897--900",
journal = "Nature Methods",
issn = "1548-7091",
publisher = "Nature Research",
number = "9",
}